Zhu Yuanping, He Sihai, Liao Kang, Li Meihua, Zhao Zhibin, Jiang Hongyan
Otolaryngology-Head and Neck Surgery Hospital of Hainan Province, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, China.
J Clin Med. 2023 Feb 13;12(4):1478. doi: 10.3390/jcm12041478.
We aimed to characterize the clinical profiles and short-term outcomes of adult patients with full-frequency idiopathic sudden sensorineural hearing loss (ISSNHL) treated uniformly with combination therapy, and to determine the prognostic predictors for the combination therapy. A total of 131 eligible cases hospitalized in our department from January 2018 to June 2021 were retrospectively reviewed. All enrolled cases received a standardized combination therapy employing intravenous methylprednisolone, batroxobin, and extract during the 12 days of hospitalization. The clinical and audiometric profiles were compared between recovered patients and their unrecovered counterparts. The overall recovery rate was 57.3% in the study. Accompanying vertigo (odds ratio = 0.360, = 0.006) and body mass index (BMI, odds ratio = 1.158, = 0.016) were two independent predictors of hearing outcomes of the therapy. The male gender and cigarette-smoking history were marginally associated with good hearing prognosis ( = 0.051 and 0.070, respectively). Patients with BMI ≥ 22.4 kg/m had a better chance of hearing recovery ( = 0.02). Conclusions: Accompanying vertigo and low BMI (<22.4 kg/m) were independently associated with poor prognosis for full-frequency ISSNHL in combination therapy. Male gender and cigarette-smoking history might be considered positive effects on hearing prognosis.
我们旨在描述接受联合治疗的全频特发性突发性感音神经性听力损失（ISSNHL）成年患者的临床特征和短期预后，并确定联合治疗的预后预测因素。回顾性分析了2018年1月至2021年6月在我科住院的131例符合条件的病例。所有纳入病例在住院12天期间均接受了标准化的联合治疗，包括静脉注射甲泼尼龙、巴曲酶和提取物。比较了康复患者和未康复患者的临床和听力检查结果。本研究的总体康复率为57.3%。伴眩晕（比值比=0.360，P=0.006）和体重指数（BMI，比值比=1.158，P=0.016）是该治疗听力结果的两个独立预测因素。男性和吸烟史与良好的听力预后有边缘相关性（分别为P=0.051和0.070）。BMI≥22.4kg/m²的患者听力恢复的机会更大（P=0.02）。结论：伴眩晕和低BMI（<22.4kg/m²）与联合治疗的全频ISSNHL预后不良独立相关。男性和吸烟史可能被认为对听力预后有积极影响。
