1 Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
2 UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Int J Stroke. 2019 Jun;14(4):359-371. doi: 10.1177/1747493019830321. Epub 2019 Feb 14.
Perivascular spaces, visible on brain magnetic resonance imaging, are thought to be associated with small vessel disease, neuroinflammation, and to be important for cerebral hemodynamics and interstitial fluid drainage.
To benchmark current knowledge on perivascular spaces associations with risk factors, neurological disorders, and neuroimaging lesions, using systematic review and meta-analysis.
We searched three databases for perivascular spaces publications, calculated odds ratios with 95% confidence interval and performed meta-analyses to assess adjusted associations with perivascular spaces. We identified 116 relevant studies ( = 36,108) but only 23 ( = 12,725) were meta-analyzable. Perivascular spaces assessment, imaging and clinical definitions varied. Perivascular spaces were associated (; OR, 95%CI, ) with ageing (8395; 1.47, 1.28-1.69, = 0.00001), hypertension (7872; 1.67, 1.20-2.31, = 0.002), lacunes (4894; 3.56, 1.39-9.14, = 0.008), microbleeds (5015; 2.26, 1.04-4.90, = 0.04) but not WMH (4974; 1.54, 0.71-3.32, = 0.27), stroke or cognitive impairment. There was between-study heterogeneity. Lack of appropriate data on other brain disorders and demographic features such as ethnicity precluded analysis.
Despite many studies, more are required to determine potential pathophysiological perivascular spaces involvement in cerebrovascular, neurodegenerative and neuroinflammatory disorders.
脑磁共振成像上可见的血管周围间隙被认为与小血管疾病、神经炎症有关，并且对脑血流动力学和细胞外液引流很重要。
使用系统评价和荟萃分析来评估血管周围间隙与危险因素、神经疾病和神经影像学病变的关联。
我们在三个数据库中搜索血管周围间隙的出版物，计算比值比及其 95%置信区间，并进行荟萃分析以评估血管周围间隙的调整关联。我们确定了 116 项相关研究（ = 36,108），但只有 23 项（ = 12,725）可以进行荟萃分析。血管周围间隙评估、成像和临床定义存在差异。血管周围间隙与年龄增长（8395；1.47，1.28-1.69， = 0.00001）、高血压（7872；1.67，1.20-2.31， = 0.002）、腔隙性梗死（4894；3.56，1.39-9.14， = 0.008）、微出血（5015；2.26，1.04-4.90， = 0.04）相关，但与脑白质病变（4974；1.54，0.71-3.32， = 0.27）、卒中和认知障碍无关。存在研究间异质性。缺乏其他脑疾病和种族等人口统计学特征的适当数据，限制了分析。
尽管有许多研究，但仍需要更多研究来确定血管周围间隙在脑血管、神经退行性和神经炎症性疾病中的潜在病理生理作用。
