Spiegel David R, Glad Rachel, Smith Melanie, Raja Uzair, Wade Ryan, Johnson Kelsey
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA.
Clin Neuropharmacol. 2019 Mar/Apr;42(2):57-59. doi: 10.1097/WNF.0000000000000327.
Catatonia is a distinct psychomotor syndrome that involves a constellation of up to 40 different symptoms. Although conventionally responsive to benzodiazepines, the catatonic syndrome is much more resistant to benzodiazepine treatment when a feature of schizophrenia.
We present a patient with schizophrenia with catatonic symptoms, marginally responsive to lorazepam challenge, lorazepam, and olanzapine monotherapy, but ultimately began combination treatment with these 2 medications.
Our patient's score on the Bush-Francis Catatonia Rating Scale significantly decreased after 2 weeks of combination lorazepam and olanzapine without adverse effects.
We propose a modification to the standard treatment protocol for catatonia, especially in those patients with schizophrenia with catatonic features.
紧张症是一种独特的精神运动综合征，涉及多达40种不同症状。虽然传统上对苯二氮䓬类药物有反应，但当紧张症综合征是精神分裂症的一个特征时，对苯二氮䓬类药物治疗的抵抗性要强得多。
我们报告一名患有紧张症症状的精神分裂症患者，对劳拉西泮激发试验、劳拉西泮及奥氮平单药治疗反应微弱，但最终开始使用这两种药物联合治疗。
在劳拉西泮和奥氮平联合治疗2周后，我们的患者在布什-弗朗西斯紧张症评定量表上的得分显著下降，且无不良反应。
我们建议对紧张症的标准治疗方案进行修改，尤其是针对那些具有紧张症特征的精神分裂症患者。
