Lou Li-Li, Zhang Ying, Huang Xu, Zhang Li-Xia, Ji Hui-Fan, Li Xu, Guo Xiao-Lin
Department of Hepatology, The First Hospital of Jilin University, Chang Chun 130021, China.
Medicine (Baltimore). 2019 Feb;98(7):e14368. doi: 10.1097/MD.0000000000014368.
Hepatocellular carcinoma (HCC) is the fifth most common cancer and third leading cause of cancer-related deaths worldwide. Nasopharyngeal metastasis of hepatocellular carcinoma is very rare. This is the first report of posttransplantation nasopharyngeal metastasis.
A 45-year-old man with a history of hepatitis B related hepatocellular carcinoma (HCC) in the right segment of the liver received an orthotopic liver transplant. Two year after the transplantation, he suffered from severe headache, and head contrast enhanced CT scans did not show clues for brain or skull metastasis. Then he developed hoarseness and dysphagia.
The nasopharyngeal cancer was confirmed to be metastatic tumor from liver histologically according to biopsy.
This patient underwent radiotherapy (RT) of the metastatic nasopharyngeal tumor, and there was significant symptomatic relief.
The patient died 3 months after nasopharyngeal metastasis was diagnosed.
Recurrence of hepatocellular carcinoma with metastasis of nasopharyngeal carcinoma after liver transplantation is rare, but the prognosis is very poor. Close follow-up of patients should be paid attention to prevent the occurrence of such diseases.
肝细胞癌（HCC）是全球第五大常见癌症，也是癌症相关死亡的第三大主要原因。肝细胞癌的鼻咽转移非常罕见。这是首例肝移植术后鼻咽转移的报告。
一名45岁男性，有乙型肝炎相关的右肝段肝细胞癌（HCC）病史，接受了原位肝移植。移植两年后，他出现严重头痛，头部增强CT扫描未显示脑或颅骨转移的线索。随后他出现声音嘶哑和吞咽困难。
经活检，鼻咽部癌症在组织学上被确认为来自肝脏的转移瘤。
该患者接受了转移性鼻咽肿瘤的放射治疗（RT），症状得到明显缓解。
患者在被诊断为鼻咽转移后3个月死亡。
肝移植后肝细胞癌复发并伴有鼻咽癌转移很罕见，但预后很差。应密切关注患者的随访情况，以预防此类疾病的发生。
