Yang Xia, Niu Kecheng, Zhang Xiaoyan, Gao Baiqing, Feng Bo, Si Ha
Department of Pharmacy.
Department of Hand, Foot and Ankie Surgery.
Medicine (Baltimore). 2019 Feb;98(7):e14571. doi: 10.1097/MD.0000000000014571.
Bone fractures are a common occurrence, and, according to clinical investigations, approximately 5% to 10% of patients with fractures will suffer from delayed healing or even non-healing. The high efficacy of traditional Chinese medicine in promoting fracture healing has been fully verified over a long history of diagnosis and treatment. Traditional Chinese medicine has a long history of applying Chinese herbs to treat fractures. Cervus and cucumis polypeptide injection has been widely used to promote fracture healing after fracture surgery in clinic, but its efficacy and safety are controversial. For the above reasons, the purpose of this study is to systematically evaluate the efficacy and safety of cervus and cucumis polypeptide injection in promoting fracture healing after bone fracture surgeries and to provide a theoretical basis for the selection of appropriate treatment measures for delayed healing of patients with fractures.
A total of 8 databases were searched, including the non-Chinese-language databases PubMed, The Cochrane Library, Web of Science, and Embase and the Chinese databases Chongqing VIP Chinese Journal Service Platform (VIP), Wanfang Data Knowledge Service Platform (Wanfang Data), SinoMed and Chinese National Knowledge Infrastructure (CNKI). The databases were queried for publicly released randomized controlled trials of the effectiveness and safety of Cervus and Cucumis polypeptide injection for fracture healing after surgical treatment, and no language restrictions were imposed. The software Review Manager 5.3 was used to evaluate the quality of the selected documents, and Stata 12.0 software was used for statistical analysis.
This review will be to assess the efficacy and safety of cervus and cucumis polypeptide injection in promoting fracture healing after bone fracture surgeries.
Our study will use systematic evaluation to objectively evaluate the efficacy and safety of cervus and cucumis polypeptide injection in promoting fracture healing after fracture surgery. It will provide theoretical basis for guiding clinical practice and benefit more patients.
This study is a systematic review that does not require ethical approval and meets the requirements of protocol for a systematic review and meta-analysis. At the same time, this study does not involve the recruitment of patients. All data are from published academic papers.
A protocol had been registered for this systematic review and meta-analysis in PROSPERO. (registration number: CRD42019120965).
骨折是一种常见病症，根据临床调查，约5%至10%的骨折患者会出现愈合延迟甚至不愈合的情况。在长期的诊疗历史中，中药在促进骨折愈合方面的显著疗效已得到充分验证。中药应用草药治疗骨折有着悠久的历史。鹿瓜多肽注射液在临床上已被广泛用于促进骨折手术后的骨折愈合，但其疗效和安全性存在争议。基于上述原因，本研究旨在系统评价鹿瓜多肽注射液在促进骨折手术后骨折愈合方面的疗效和安全性，为骨折延迟愈合患者选择合适的治疗措施提供理论依据。
共检索了8个数据库，包括非中文数据库PubMed、The Cochrane Library、Web of Science和Embase，以及中文数据库重庆维普中文科技期刊数据库（VIP）、万方数据知识服务平台（万方数据）、中国生物医学文献数据库（SinoMed）和中国知网（CNKI）。在这些数据库中查询已公开发表的关于鹿瓜多肽注射液用于手术治疗后促进骨折愈合的有效性和安全性的随机对照试验，且不设语言限制。使用Review Manager 5.3软件评估所选取文献的质量，使用Stata 12.0软件进行统计分析。
本综述将评估鹿瓜多肽注射液在促进骨折手术后骨折愈合方面的疗效和安全性。
我们的研究将采用系统评价的方法，客观评价鹿瓜多肽注射液在促进骨折手术后骨折愈合方面的疗效和安全性。这将为指导临床实践提供理论依据，使更多患者受益。
本研究是一项系统综述，无需伦理批准，符合系统综述和荟萃分析方案的要求。同时，本研究不涉及患者招募。所有数据均来自已发表的学术论文。
本系统综述和荟萃分析已在PROSPERO中注册了方案。（注册号：CRD42019120965）
