Zhang Qi, Hu Jianan, Wei Lijiao, Cao Ri, Ma Ruishu, Song Huimin, Jin Yi
School of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin.
The Department of Nursing, Children's Hospital of Shanxi/Woman Health Center of Shanxi, Taiyuan, Shanxi.
Medicine (Baltimore). 2019 Feb;98(7):e14581. doi: 10.1097/MD.0000000000014581.
Mild cognitive impairment (MCI) can be a stage of pre-dementia. Although the traditional Chinese exercise (TCE) has benefits associated with cognitive functions, the effects of the TCE on cognitive functions of older patients with MCI remain controversial. This study performs a meta-analysis to quantify the efficiency of TCE for older individuals on cognitive and psychological outcomes.
A comprehensive database search was conducted on PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL (EBSCO), Web of Science, and four Chinese medical databases. We included trials published up to April 22, 2018, that fulfilled our inclusion and exclusion criteria. The literature was screened, the data were extracted and the methodological quality of the included trials was assessed. Meta-analyses were performed on the included data.
A total of 803 patients from 5 trials were included in our meta-analysis. Overall, there were no significant differences in global cognitive functions (P = .06), memory (P = .11), executive function (P = .74), Verbal fluency (P = .45) and depression (P = .89) between the TCE and the control groups. However, the TCE significantly improved the visuospatial function (SMD = 0.38, 95% CI = 0.22 to 0.54; P < .001) for individuals with MCI.
The findings of this study suggested that the TCE was associated with significant improvement in visuospatial function but did not affect the global cognitive functions, depression and other specific cognitive domains. There is a lack of clear evidence for effects of TCE; further large, rigorously designed studies are needed.
轻度认知障碍（MCI）可能是痴呆前期的一个阶段。尽管传统中医运动（TCE）对认知功能有益，但TCE对老年MCI患者认知功能的影响仍存在争议。本研究进行荟萃分析，以量化TCE对老年人认知和心理结局的有效性。
在PubMed、Embase、Cochrane对照试验中心注册库（CENTRAL）、CINAHL（EBSCO）、科学引文索引和四个中国医学数据库中进行全面的数据库检索。我们纳入了截至2018年4月22日发表的符合我们纳入和排除标准的试验。对文献进行筛选、数据提取，并评估纳入试验的方法学质量。对纳入的数据进行荟萃分析。
我们的荟萃分析共纳入了来自5项试验的803名患者。总体而言，TCE组和对照组在整体认知功能（P = 0.06）、记忆（P = 0.11）、执行功能（P = 0.74）、语言流畅性（P = 0.45）和抑郁（P = 0.89）方面没有显著差异。然而，TCE显著改善了MCI患者的视觉空间功能（标准化均数差=0.38，95%置信区间=0.22至0.54；P<0.001）。
本研究结果表明，TCE与视觉空间功能的显著改善相关，但不影响整体认知功能、抑郁和其他特定认知领域。缺乏TCE效果的明确证据；需要进一步开展大规模、设计严谨的研究。
