传统中医运动对慢性阻塞性肺疾病患者的影响：一项荟萃分析。

The Effects of Traditional Chinese Exercise in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis.

作者信息

Luo Xiaotian, Zhang Jifeng, Castelberg Rachel, Wu Tao, Yu Pengming, He Chengqi, Wang Pu

机构信息

Department of Rehabilitation Medicine Center, Sichuan University, West China Hospital, Chengdu, Sichuan, PR China.

Department of Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, PR China.

出版信息

PLoS One. 2016 Sep 2;11(9):e0161564. doi: 10.1371/journal.pone.0161564. eCollection 2016.

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide. However, several studies that have assessed the role of traditional Chinese exercise in the management of this disease include broad variations in sample sizes and results. Therefore, this meta-analysis was conducted to assess the effects of traditional Chinese exercise on patients with COPD.

METHODS

Two investigators independently identified and extracted data from selected articles. A computerized search of electronic databases through August 2015 was conducted. Mean differences (MDs) and 95% confidence intervals (CIs) were calculated to analyze the combined data. The methodological quality was evaluated using the Cochrane risk-of-bias tool. Heterogeneity was assessed with the I2 test.

RESULTS

Ten randomized, controlled trials (RCTs) involving 622 patients met the inclusion criteria. There were significant improvements in the 6-minute walking distance test (6 MWD;MWD = 12.10 m; 95% CI, 7.56-16.65 m; p<0.001); forced expiratory volume in one second (FEV1% predicted; WMD = 9.02; 95% CI, 6.80-11.23; p<0.00001); forced expiratory volume in 1 second/forced vital capacity (FEV(1)/FVC) ratio (Tiffenau Index; WMD = 6.67; 95% CI, 5.09-8.24; p<0.00001); and quality of life, as evaluated by the Chronic Respiratory Disease Questionnaire (CRDQ; WMD = 0.85 score; 95% CI, 0.52-1.18; p<0.00001).

CONCLUSIONS

Traditional Chinese exercise could provide an effective alternative method for managing COPD. Larger and higher-quality trials are required.

背景

慢性阻塞性肺疾病（COPD）是全球主要的公共卫生问题。然而，几项评估传统中式锻炼在该疾病管理中作用的研究，在样本量和结果方面存在广泛差异。因此，进行了这项荟萃分析以评估传统中式锻炼对COPD患者的影响。

方法

两名研究者独立从选定文章中识别并提取数据。对截至2015年8月的电子数据库进行了计算机化检索。计算平均差（MDs）和95%置信区间（CIs）以分析合并数据。使用Cochrane偏倚风险工具评估方法学质量。用I²检验评估异质性。

结果

10项涉及622例患者的随机对照试验（RCTs）符合纳入标准。6分钟步行距离测试（6MWD；MWD = 12.10米；95%CI，7.56 - 16.65米；p<0.001）、一秒用力呼气量（FEV1%预计值；WMD = 9.02；95%CI，6.80 - 11.23；p<0.00001）、一秒用力呼气量/用力肺活量（FEV(1)/FVC）比值（蒂芬诺指数；WMD = 6.67；95%CI，5.09 - 8.24；p<0.00001）以及慢性呼吸系统疾病问卷（CRDQ）评估的生活质量（WMD = 0.85分；95%CI，0.52 - 1.18；p<0.00001）均有显著改善。