主动脉瘤形成的细胞机制。
Cellular Mechanisms of Aortic Aneurysm Formation.
机构信息
From the Division of Cardiology, Department of Medicine (R.A.Q., W.R.T.), Emory University School of Medicine, Atlanta, GA.
Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology (W.R.T.), Emory University School of Medicine, Atlanta, GA.
出版信息
Circ Res. 2019 Feb 15;124(4):607-618. doi: 10.1161/CIRCRESAHA.118.313187.
Abstract
Aortic aneurysms are a common vascular disease in Western populations that can involve virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than thoracic aortic aneurysms and combined they account for >25 000 deaths in the United States annually. Although thoracic and abdominal aortic aneurysms share some common characteristics, including the gross anatomic appearance, alterations in extracellular matrix, and loss of smooth muscle cells, they are distinct diseases. In recent years, advances in genetic analysis, robust molecular tools, and increased availability of animal models have greatly enhanced our knowledge of the pathophysiology of aortic aneurysms. This review examines the various proposed cellular mechanisms responsible for aortic aneurysm formation and identifies opportunities for future studies.
摘要
主动脉瘤是西方人群中一种常见的血管疾病，可以涉及主动脉的几乎任何部位。腹主动脉瘤比胸主动脉瘤更为常见，两者加起来每年导致美国超过 25000 人死亡。尽管胸主动脉瘤和腹主动脉瘤有一些共同的特征，包括大体解剖外观、细胞外基质的改变和平滑肌细胞的丧失，但它们是两种不同的疾病。近年来，遗传分析、强大的分子工具和更多动物模型的可用性的进步极大地提高了我们对主动脉瘤病理生理学的认识。本综述检查了各种已提出的负责主动脉瘤形成的细胞机制，并确定了未来研究的机会。
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