Öster Hannes, Chen Trina, Mennander Ari, Paavonen Timo, Kholová Ivana
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Department of Pathology, Fimlab Laboratories, Tampere, Finland.
J Histochem Cytochem. 2025 May-Jun;73(5-6):237-249. doi: 10.1369/00221554251350743. Epub 2025 Jun 24.
Chemokine-like receptor 1 (CMKLR-1) is a G-protein-coupled receptor that functions as the binding site of chemerin. It induces chemotaxis in various immune cells, and it has recently been linked to vascular remodeling in inflammation. In this study, we investigated CMKLR-1 expression in human aorta samples, focusing on its distribution across different cell types and its potential association with clinical and histomorphological data, particularly concerning aortic dissection and aneurysms. We analyzed 62 aorta samples taken from patients undergoing dissection surgery (n = 27) or aneurysm/dilatation (n = 35) using immunohistochemical CMKLR-1 staining. CMKLR-1 expression was primarily observed in the smooth muscle cells (SMCs) of the aortic media layer, and band-like coloring appeared in the unstained center section. CMKLR-1 positivity in the inner and outer parts of the media layer was observed in only a few cases. One-third of the vasa vasorum exhibited staining. Staining in lymphocytes, macrophages, and endothelia was rare. No significant differences in CMKLR-1 expression were found between the dissection and aneurysm cases, and the clinical or histomorphological data. Although CMKLR-1 expression did not distinguish between the studied conditions, its presence in the aortic media, especially in SMCs, is noteworthy.
趋化因子样受体1（CMKLR-1）是一种G蛋白偶联受体，作为化学引诱素的结合位点发挥作用。它可诱导多种免疫细胞的趋化作用，最近还与炎症中的血管重塑相关。在本研究中，我们调查了人主动脉样本中CMKLR-1的表达情况，重点关注其在不同细胞类型中的分布以及它与临床和组织形态学数据的潜在关联，特别是关于主动脉夹层和动脉瘤方面。我们使用免疫组化CMKLR-1染色分析了62份取自接受夹层手术患者（n = 27）或动脉瘤/扩张患者（n = 35）的主动脉样本。CMKLR-1表达主要见于主动脉中层的平滑肌细胞（SMC），未染色的中央部分呈带状着色。仅在少数病例中观察到中层内外部分的CMKLR-1阳性。三分之一的滋养血管有染色。淋巴细胞、巨噬细胞和内皮细胞中的染色罕见。在夹层和动脉瘤病例以及临床或组织形态学数据之间，未发现CMKLR-1表达有显著差异。尽管CMKLR-1表达未能区分所研究的情况，但其在主动脉中层尤其是SMC中的存在值得关注。
