Vidas I, Temmer K, Zuzić P, Palaversić M
Acta Stomatol Croat. 1988;22(4):311-7.
The potential presence of Candida albicans in oral leukokeratotic lesions, also entailing the need of additional antimiotic therapy, has been quite extensively discussed in literature. Therefore, the aim of this study was to assess the prevalence of Candida albicans isolates in subjects with oral leukoplakia as well as of candidal leukoplakia according to oral mucosa regions. The study included 60 subjects, mean age 46 years. A study group had 28 subjects with oral leukoplakia, whereas a control group comprised subjects free of any pathological alterations of oral mucosa. In all subjects, a clinical oral examination was performed and material for microbiological analysis taken. Following cultivation and incubation, tests of identification and microbiological analysis were carried out on the material thus grown. Results of the study revealed that Candida albicans was present in 67.9% of subjects with oral leukoplakia, which is the highest percentage reported on so far, and in 28.1% of subjects without any pathologic alterations of oral mucosa. The prevalence of candidal leukoplakia was found to be highest in oral mucosa, followed by lips, tongue and sublingual mucosa. Thus, these findings appear to clearly confirm the need of additional use of antimicotics, along with antikeratotic therapy of leukoplakia.
口腔白色角化病损中白色念珠菌的潜在存在，这也需要额外的抗真菌治疗，在文献中已有相当广泛的讨论。因此，本研究的目的是根据口腔黏膜区域评估口腔白斑患者以及念珠菌性白斑患者中白色念珠菌分离株的患病率。该研究纳入了60名受试者，平均年龄46岁。研究组有28名口腔白斑患者，而对照组包括口腔黏膜无任何病理改变的受试者。对所有受试者进行了口腔临床检查并采集了微生物分析样本。培养和孵育后，对培养所得样本进行鉴定测试和微生物分析。研究结果显示，67.9%的口腔白斑患者存在白色念珠菌，这是迄今为止报道的最高比例，而28.1%口腔黏膜无任何病理改变的受试者也存在白色念珠菌。念珠菌性白斑的患病率在口腔黏膜中最高，其次是嘴唇、舌头和舌下黏膜。因此，这些发现似乎清楚地证实了在白斑抗角化治疗的同时额外使用抗真菌药物的必要性。
