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中文旅行者中的库氏疟原虫和沃氏疟原虫:非洲大陆环子孢子蛋白新型基因型的流行情况。

Plasmodium ovale curtisi and Plasmodium ovale wallikeri in Chinese travelers: Prevalence of novel genotypes of circumsporozoite protein in the African continent.

机构信息

Department of Parasitology, Institute of Translational Medicine, Medical College, Yangzhou University, Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Yangzhou 225001, Jiangsu Province, People's Republic of China; Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, Jiangsu Province, People's Republic of China.

Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea.

出版信息

Infect Genet Evol. 2019 Jun;70:9-14. doi: 10.1016/j.meegid.2019.02.008. Epub 2019 Feb 11.

DOI:10.1016/j.meegid.2019.02.008
PMID:30763775
Abstract

Imported malaria due to Plasmodium ovale curtisi and P. ovale wallikeri infections from African countries has increased recently (2011-2014) in Chinese travelers. We report novel genotypes, their prevalence and the predominant haplotypes of P. ovale curtisi and P. ovale wallikeri circumsporozoite protein (CSP) from 20 African countries in Chinese travelers. These genotypes should be considered while designing a CSP-based vaccine against P. ovale malaria.

摘要

最近(2011-2014 年),从非洲国家输入的卵形疟原虫 curtisi 和卵形疟原虫 wallikeri 感染导致中国旅行者中的输入性疟疾有所增加。我们报告了来自 20 个非洲国家的中国旅行者中的卵形疟原虫 curtisi 和卵形疟原虫 wallikeri 环子孢子蛋白(CSP)的新型基因型、其流行情况和主要单倍型。在设计针对卵形疟原虫疟疾的 CSP 疫苗时,应考虑这些基因型。

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