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肠磷酸盐吸收:细胞旁途径占主导地位?

Intestinal phosphate absorption: The paracellular pathway predominates?

机构信息

1 Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2R7, Canada.

2 The Women's & Children's Health Research Institute, Edmonton, Alberta T6G 1C9, Canada.

出版信息

Exp Biol Med (Maywood). 2019 May;244(8):646-654. doi: 10.1177/1535370219831220. Epub 2019 Feb 14.

DOI:10.1177/1535370219831220
PMID:30764666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6552399/
Abstract

This review summarizes the work on transcellular intestinal phosphate absorption, arguing why this pathway is not the predominant pathway in humans consuming a "Western" diet. We then highlight the recent evidence which is strongly consistent with paracellular intestinal phosphate absorption mediating the bulk of intestinal phosphate absorption in humans.

摘要

这篇综述总结了细胞间肠道磷酸盐吸收的相关研究,论证了为什么该途径不是人类摄入“西方”饮食时的主要途径。然后,我们强调了最近的证据,这些证据强烈表明,细胞旁肠道磷酸盐吸收是人类肠道磷酸盐吸收的主要途径。

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本文引用的文献

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Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi).维生素 D、甲状旁腺激素(PTH)和磷酸盐(Pi)对磷酸盐的生理调节。
Pflugers Arch. 2019 Jan;471(1):83-98. doi: 10.1007/s00424-018-2231-z. Epub 2018 Nov 5.
2
Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.胃肠道钠/氢交换器 3 的抑制作用可降低 Tenapanor 的细胞旁磷酸盐通透性。
Sci Transl Med. 2018 Aug 29;10(456). doi: 10.1126/scitranslmed.aam6474.
3
The effects of tenapanor on serum fibroblast growth factor 23 in patients receiving hemodialysis with hyperphosphatemia.在高磷血症接受血液透析的患者中,替纳普诺对血清成纤维细胞生长因子 23 的影响。
Nephrol Dial Transplant. 2019 Feb 1;34(2):339-346. doi: 10.1093/ndt/gfy061.
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The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of plasma inorganic phosphate concentration.钠离子-磷酸盐协同转运蛋白家族和烟酰胺磷酸核糖基转移酶有助于血浆无机磷酸盐浓度的日常波动。
Kidney Int. 2018 May;93(5):1073-1085. doi: 10.1016/j.kint.2017.11.022. Epub 2018 Feb 15.
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NPT-IIb Inhibition Does Not Improve Hyperphosphatemia in CKD.NPT-IIb抑制并不能改善慢性肾脏病患者的高磷血症。
Kidney Int Rep. 2017 Aug 12;3(1):73-80. doi: 10.1016/j.ekir.2017.08.003. eCollection 2018 Jan.
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