Zhou Yeye, Li Jihui, Xu Xin, Zhao Man, Zhang Bin, Deng Shengming, Wu Yiwei
1 Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819830758. doi: 10.1177/1533033819830758.
Copper-64 (T = 12.7 hours; β: 19%, β: 38%) has a unique decay profile and can be used for positron emission tomography imaging and radionuclide therapy. The well-established coordination chemistry of copper allows for its reaction with different types of chelator systems. It can be linked to antibodies, proteins, peptides, and other biologically relevant small molecules. Two potential ways to produce copper-64 radioisotopes concern the use of the cyclotron or the reactor. This review summarized several commonly used biomarkers of copper-64 radionuclide.
铜-64（半衰期T = 12.7小时；β⁺发射率为19%，β⁻发射率为38%）具有独特的衰变特性，可用于正电子发射断层扫描成像和放射性核素治疗。铜已确立的配位化学性质使其能够与不同类型的螯合剂体系发生反应。它可以与抗体、蛋白质、肽以及其他具有生物学相关性的小分子相连。生产铜-64放射性同位素的两种潜在方法涉及使用回旋加速器或反应堆。本综述总结了几种常用的铜-64放射性核素生物标志物。
