Blower P J, Lewis J S, Zweit J
Nuclear Medicine Dept., Kent and Canterbury Hospital, UK.
Nucl Med Biol. 1996 Nov;23(8):957-80. doi: 10.1016/s0969-8051(96)00130-8.
The chemistry, radiochemistry, radiobiology, and radiopharmacology of radiopharmaceuticals containing copper radionuclides are reviewed. Copper radionuclides offer application in positron emission tomography, targeted radiotherapy, and single photon imaging. The chemistry of copper is relatively simple and well-suited to radiopharmaceutical application. Current radiopharmaceuticals include biomolecules labelled via bifunctional chelators primarily based on cyclic polyaminocarboxylates and polyamines, and pyruvaldehyde-bis(N4-methylthiosemicarbazone) (PTSM) and its analogues. The chemistry of copper, of which only a fraction has yet been exploited, is likely to be applied more fully in the future.
本文综述了含铜放射性核素的放射性药物的化学、放射化学、放射生物学和放射药理学。铜放射性核素可应用于正电子发射断层扫描、靶向放射治疗和单光子成像。铜的化学性质相对简单，非常适合放射性药物应用。目前的放射性药物包括主要基于环状多氨基羧酸盐和多胺的双功能螯合剂标记的生物分子，以及丙酮醛-双（N4-甲基硫代半卡巴腙）（PTSM）及其类似物。铜的化学性质目前仅被开发了一部分，未来可能会得到更充分的应用。
