Wiedermann C J, Ruff M R, Pert C B
Department of Internal Medicine, University of Innsbruck, Austria.
Brain Behav Immun. 1988 Dec;2(4):301-10. doi: 10.1016/0889-1591(88)90032-3.
In recent years, a remarkable advance has been made in identifying the extracellular factors that control cell proliferation in a variety of cells. Bombesin-like peptides (BN-LP) are neuropeptides involved in the regulation of many important functions, including sensory transmission, regulation of central autonomic pathways, thermoregulation, pituitary, gastric, and pancreatic secretion, food intake, and satiety. They also may stimulate cellular proliferation in a developmental and tissue-specific manner. Their role in pathogenesis appears to be related to their properties as growth factors, especially in the lung, where BN-LP are proposed to induce growth of normal and neoplastic epithelial cells. The formulated hypothesis of control of SCLC growth by BN-LP will be tested using specific synthetic BN antagonists. Neuronal modulation of the release of BN-LP from neuroepithelial bodies and paracrine effects of BN-LP as sensory neurotransmitters indicate possible pathways of nervous system involvement in tissue development, proliferation, and differentiation, as well as repair processes and wound healing.
近年来，在识别控制各种细胞中细胞增殖的细胞外因子方面取得了显著进展。蛙皮素样肽（BN-LP）是参与调节许多重要功能的神经肽，包括感觉传递、中枢自主神经通路调节、体温调节、垂体、胃和胰腺分泌、食物摄入和饱腹感。它们还可能以发育和组织特异性方式刺激细胞增殖。它们在发病机制中的作用似乎与其作为生长因子的特性有关，尤其是在肺部，有人提出BN-LP可诱导正常和肿瘤上皮细胞生长。将使用特定的合成BN拮抗剂来检验关于BN-LP控制小细胞肺癌生长的既定假设。神经上皮体释放BN-LP的神经元调节以及BN-LP作为感觉神经递质的旁分泌作用表明，神经系统可能参与组织发育、增殖、分化以及修复过程和伤口愈合。
