Panula P
Med Biol. 1986;64(4):177-92.
Bombesin-like peptides are a group of brain-gut peptides found in several neuronal groups in the central nervous system and in peripheral intrinsic gut neurons and sensory neurons. The SIF cells (small intensely fluorescent cells) of the sympathetic ganglia also contain immunoreactivity for these peptides. These peptides are present in some pulmonary endocrine cells and tumors originating from these cells. Chromatographic studies suggest that several different peptides, possibly originating from at least two different precursors, are present in mammalian tissues. Authentic amphibian peptide bombesin does not appear to be found in mammalian tissues. Functional studies indicate that these peptides may be involved in many important functions, including sensory transmission, regulation of central autonomic pathways, thermoregulation, secretion of pituitary hormones, gastric and pancreatic secretion, food intake and satiety.
蛙皮素样肽是一类脑肠肽，存在于中枢神经系统的多个神经元群以及外周肠道固有神经元和感觉神经元中。交感神经节的SIF细胞（小而强荧光细胞）也对这些肽具有免疫反应性。这些肽存在于一些肺内分泌细胞以及源自这些细胞的肿瘤中。色谱研究表明，哺乳动物组织中存在几种不同的肽，可能源自至少两种不同的前体。在哺乳动物组织中似乎未发现真正的两栖类肽蛙皮素。功能研究表明，这些肽可能参与许多重要功能，包括感觉传递、中枢自主神经通路调节、体温调节、垂体激素分泌、胃和胰腺分泌、食物摄入和饱腹感。
