Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Pancreatology. 2019 Mar;19(2):230-236. doi: 10.1016/j.pan.2019.02.001. Epub 2019 Feb 5.
To appraise the predictive function of 'the product value of serum albumin and prothrombin time activity' (PAA) on admission for the organ failure related events of acute pancreatitis (AP).
789 patients with AP were included in this retrospective study. 468 patients generated transient organ failure (TOF). 242 were diagnosed with persistent organ failure (POF), of which 63 patients died.
All the values of laboratory parameters were measured upon admission to hospital. Dunnett'T3 test, Uni- and multi-variate ordinal logistic regression were used. ROC curve was utilized to evaluate the ultimate predictive values.
Among the patients with 4 different levels of severity of acute pancreatitis, PAA observably reduced as the disease aggravated (32.20 vs 29.56 vs 23.54 vs 17.89). PAA was also an independent risk factor for the aggravation of AP (OR: 0.873, 95% CI: 0.848, 0.899; p < 0.01). The Area Under the Curve (AUC) of PAA for OF was 0.828 (0.783, 0.872), 0.828 for POF (0.790, 0.865) and 0.905 for death cases (0.862, 0.948).
The product value of serum albumin and prothrombin time activity is a good predictor of the severity, especially the events related to organ failure of acute pancreatitis.
评价入院时“血清白蛋白和凝血酶原时间活动产物值”（PAA）对急性胰腺炎（AP）器官衰竭相关事件的预测作用。
本回顾性研究纳入了 789 例 AP 患者。其中 468 例患者发生短暂性器官衰竭（TOF），242 例患者被诊断为持续性器官衰竭（POF），其中 63 例死亡。
入院时测量所有实验室参数值。采用 Dunnett’T3 检验、单变量和多变量有序逻辑回归。ROC 曲线用于评估最终预测值。
在急性胰腺炎严重程度不同的 4 组患者中，PAA 随着病情加重而明显降低（32.20 比 29.56 比 23.54 比 17.89）。PAA 也是 AP 加重的独立危险因素（OR：0.873，95%CI：0.848，0.899；p<0.01）。PAA 对 OF 的曲线下面积（AUC）为 0.828（0.783，0.872），对 POF 的 AUC 为 0.828（0.790，0.865），对死亡病例的 AUC 为 0.905（0.862，0.948）。
血清白蛋白和凝血酶原时间活动产物值是预测严重程度的良好指标，特别是与急性胰腺炎器官衰竭相关的事件。
