Center of Liver-Biliary-Pancreatic, Taihe Hospital, Shiyan City, Hubei Province.
Department of Radiology, Yunxi People's Hospital, Shiyan City, Hubei Province.
Biosci Rep. 2019 Feb 26;39(2). doi: 10.1042/BSR20181230. Print 2019 Feb 28.
The aim of this study is to explore the safety and efficacy of Cone-Beam computed tomography (CBCT) guided radiofrequency ablation (RFA) in the treatment of pulmonary malignancies. Thirty-one patients with pulmonary malignant tumors (≤3 cm in diameter) were enrolled to this study. Total 43 CBCT guided RFA treatments were performed, including 7 patients undergoing multiple treatments. The target tumor puncture success rate, tumor remission rate, postoperative cumulative survival rate, tumor-free survival rate and complication rate were analyzed. All 43 CBCT guided RFA procedures successfully punctured the target tumors. Complications included five cases of pneumothorax and three cases of hemoptysis. For the 31 patients who underwent CBCT guided RFA, the 1- and 2-year cumulative survival rates were 80.6 and 54.8%, respectively. The 1- and 2-year disease-free survival rates were 54.8 and 32.3%, respectively. The 1-, 3- and 6-month remission rates were 78.4, 68.7 and 63.3%, respectively. The average cumulative radiation dose and average effective radiation dose were 194.62 ± 105.51 mGy and 5.41 ± 3.45 mSv, respectively. CBCT help to shorten the operation time, reduce the unnecessary interventions and also reduce the incidence of complications. CBCT guided RFA is one safe and efficacious treatment for pulmonary malignancies.
本研究旨在探讨锥形束 CT（CBCT）引导下射频消融（RFA）治疗肺部恶性肿瘤的安全性和有效性。共纳入 31 例肺部恶性肿瘤（直径≤3cm）患者，共进行 43 次 CBCT 引导下 RFA 治疗，其中 7 例患者行多次治疗。分析了靶肿瘤穿刺成功率、肿瘤缓解率、术后累积生存率、无瘤生存率和并发症发生率。所有 43 次 CBCT 引导下 RFA 手术均成功穿刺靶肿瘤。并发症包括气胸 5 例，咯血 3 例。31 例接受 CBCT 引导下 RFA 的患者，1 年和 2 年累积生存率分别为 80.6%和 54.8%，1 年和 2 年无瘤生存率分别为 54.8%和 32.3%，1、3 和 6 个月的缓解率分别为 78.4%、68.7%和 63.3%。平均累积辐射剂量和平均有效辐射剂量分别为 194.62±105.51mGy 和 5.41±3.45mSv。CBCT 有助于缩短手术时间、减少不必要的干预，并降低并发症发生率。CBCT 引导下 RFA 是治疗肺部恶性肿瘤的一种安全有效的方法。
