Umashankar M S, Kumar A Bharath
Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kanchipuram, Tamil Nadu, India.
Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kanchipuram, Tamil Nadu, India.
J Neurosci Rural Pract. 2019 Jan-Mar;10(1):154-157. doi: 10.4103/jnrp.jnrp_191_18.
Absence seizures are often associated with impaired or loss of consciousness clinically proved to have an impact on motor and cognitive abnormalities of the nerve cells of the brain. Seizure admits several etiopathophysiological events leading to several neurofunctional changes in the reticulothalamocortical circuitry zones of the central nervous system. This paves the episodes of absence seizure events. A clinical case report of absence seizure in a 25 years age adult patient came to the hospital with impaired consciousness. The brain magnetic resonance imaging scanning of the patient detected a small focal flair hypertensive area in the right parasellar region close to cavernous sinus with mild flair hypersensitivity in the left cavernous sinuses, right maxillary, and ethmoid sinusitis. The electroencephalogram of the brain showed normal waves with electrode artifacts was observed. The patient was confirmed with absence seizures, and he was treated with oxcarbazepine 150 mg twice daily. The patient was recovered from seizure and discharged with medications. He was called for follow-up examination once in 3-month period.
失神发作通常与意识受损或丧失有关，临床证明其会对大脑神经细胞的运动和认知异常产生影响。癫痫发作包含多种病因病理生理事件，这些事件会导致中枢神经系统网状丘脑皮质回路区域出现多种神经功能变化。这为失神发作事件的发作奠定了基础。一名25岁成年患者因意识受损前来医院，这是一例失神发作的临床病例报告。该患者的脑部磁共振成像扫描在靠近海绵窦的右侧鞍旁区域检测到一个小的局灶性片状高血压区域，左侧海绵窦、右侧上颌窦和筛窦有轻度片状高敏反应。脑部脑电图显示观察到有电极伪影的正常波。该患者被确诊为失神发作，给予奥卡西平每日两次，每次150毫克进行治疗。患者的癫痫发作得到缓解并带药出院。要求他每3个月进行一次随访检查。
