老年住院患者质子泵抑制剂暴露与感染之间的关联
Association Between Proton Pump Inhibitor Exposure and Infection in Elderly, Hospitalized Patients.
作者信息
Ross Denise, Gable Catherine, Rentsch Christopher T
机构信息
and are clinical pharmacy specialists, and is an epidemiologist, all at the Atlanta VAMC in Georgia.
出版信息
Fed Pract. 2015 Nov;32(11):21-25.
Abstract
This study did not find a statistically significant association between infections and use of proton pump inhibitors.
摘要
本研究未发现感染与质子泵抑制剂的使用之间存在统计学上的显著关联。
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本文引用的文献
1
Continuous Proton Pump Inhibitor Therapy and the Associated Risk of Recurrent Clostridium difficile Infection.连续质子泵抑制剂治疗与复发性艰难梭菌感染的相关风险。
JAMA Intern Med. 2015 May;175(5):784-91. doi: 10.1001/jamainternmed.2015.42.
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Proton Pump Inhibitors and the Risk for Hospital-Acquired Clostridium difficile Infection.质子泵抑制剂与医院获得性艰难梭菌感染的风险。
Mayo Clin Proc. 2013 Oct;88(10):1085-90. doi: 10.1016/j.mayocp.2013.07.004. Epub 2013 Sep 5.
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Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis.艰难梭菌相关性腹泻与质子泵抑制剂治疗：一项荟萃分析。
Am J Gastroenterol. 2012 Jul;107(7):1001-10. doi: 10.1038/ajg.2012.179. Epub 2012 Jun 19.
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Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis.抑酸药物和抗生素与艰难梭菌感染风险：荟萃分析。
Am J Gastroenterol. 2012 Jul;107(7):1011-9. doi: 10.1038/ajg.2012.108. Epub 2012 Apr 24.
5
Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection.医源性胃酸抑制与医院获得性艰难梭菌感染风险
Arch Intern Med. 2010 May 10;170(9):784-90. doi: 10.1001/archinternmed.2010.89.
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Proton pump inhibitors and risk for recurrent Clostridium difficile infection.质子泵抑制剂与艰难梭菌反复感染风险
Arch Intern Med. 2010 May 10;170(9):772-8. doi: 10.1001/archinternmed.2010.73.
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Proton pump inhibitors increase significantly the risk of Clostridium difficile infection in a low-endemicity, non-outbreak hospital setting.在低流行率、无暴发的医院环境中，质子泵抑制剂会显著增加艰难梭菌感染的风险。
Aliment Pharmacol Ther. 2009 Mar 15;29(6):626-34. doi: 10.1111/j.1365-2036.2008.03924.x. Epub 2008 Dec 19.
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Infect Control Hosp Epidemiol. 2008 Sep;29(9):823-8. doi: 10.1086/588756.
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Case-control study of antibiotic use and subsequent Clostridium difficile-associated diarrhea in hospitalized patients.住院患者抗生素使用与后续艰难梭菌相关性腹泻的病例对照研究。
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