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老年住院患者质子泵抑制剂暴露与感染之间的关联

Association Between Proton Pump Inhibitor Exposure and Infection in Elderly, Hospitalized Patients.

作者信息

Ross Denise, Gable Catherine, Rentsch Christopher T

机构信息

and are clinical pharmacy specialists, and is an epidemiologist, all at the Atlanta VAMC in Georgia.

出版信息

Fed Pract. 2015 Nov;32(11):21-25.

Abstract

This study did not find a statistically significant association between infections and use of proton pump inhibitors.

摘要

本研究未发现感染与质子泵抑制剂的使用之间存在统计学上的显著关联。

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本文引用的文献

1
Continuous Proton Pump Inhibitor Therapy and the Associated Risk of Recurrent Clostridium difficile Infection.
JAMA Intern Med. 2015 May;175(5):784-91. doi: 10.1001/jamainternmed.2015.42.
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Proton Pump Inhibitors and the Risk for Hospital-Acquired Clostridium difficile Infection.
Mayo Clin Proc. 2013 Oct;88(10):1085-90. doi: 10.1016/j.mayocp.2013.07.004. Epub 2013 Sep 5.
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Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis.
Am J Gastroenterol. 2012 Jul;107(7):1001-10. doi: 10.1038/ajg.2012.179. Epub 2012 Jun 19.
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Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis.
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Proton pump inhibitors and risk for recurrent Clostridium difficile infection.
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Proton pump inhibitors increase significantly the risk of Clostridium difficile infection in a low-endemicity, non-outbreak hospital setting.
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Gastric acid suppression by proton pump inhibitors as a risk factor for clostridium difficile-associated diarrhea in hospitalized patients.
Am J Gastroenterol. 2008 Sep;103(9):2308-13. doi: 10.1111/j.1572-0241.2008.01975.x. Epub 2008 Aug 12.
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Rising economic impact of clostridium difficile-associated disease in adult hospitalized patient population.
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