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氯胺酮是治疗自杀的新型神奇药物吗?

Is Ketamine the New Wonder Drug for Treating Suicide?

作者信息

Boilini Henry, Baldwin Madeleine, Lamvu Georgine

机构信息

is a staff psychiatrist, is a clinical social worker, and is a gynecologist, all at Orlando VAMC in Florida. Dr. Lamvu also is a professor at the University of Central Florida College of Medicine in Orlando.

出版信息

Fed Pract. 2017 Sep;34(9):12-16.

PMID:30766296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6370452/
Abstract

Although the initial findings involving the use of ketamine in suicidal patients are promising, further research is needed on the short - and long-term effects of this medication.

摘要

尽管最初关于在自杀患者中使用氯胺酮的研究结果很有前景,但仍需要对这种药物的短期和长期影响进行进一步研究。

相似文献

1
Is Ketamine the New Wonder Drug for Treating Suicide?氯胺酮是治疗自杀的新型神奇药物吗?
Fed Pract. 2017 Sep;34(9):12-16.
2
The Effect of Intravenous Ketamine in Suicidal Ideation of Emergency Department Patients.静脉注射氯胺酮对急诊科患者自杀意念的影响。
Emerg (Tehran). 2014 Winter;2(1):36-9.
3
Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study.重复静脉注射氯胺酮后当前自杀观念迅速且持续减轻:一项开放标签研究的二次分析
J Clin Psychiatry. 2016 Jun;77(6):e719-25. doi: 10.4088/JCP.15m10056.
4
Is Ketamine the Future Clozapine for Depression? A Case Series and Literature Review on Maintenance Ketamine in Treatment-resistant Depression With Suicidal Behavior.氯胺酮会成为未来治疗抑郁症的氯氮平吗?关于维持使用氯胺酮治疗伴有自杀行为的难治性抑郁症的病例系列及文献综述
J Psychiatr Pract. 2018 Jul;24(4):279-291. doi: 10.1097/PRA.0000000000000316.
5
Antisuicidal Effects of Ketamine: A Promising First Step.氯胺酮的抗自杀作用:充满希望的第一步。
Am J Psychiatry. 2018 Feb 1;175(2):97-98. doi: 10.1176/appi.ajp.2017.17111261.
6
Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial.重复剂量氯胺酮增效治疗伴有慢性自杀意念的难治性抑郁症:一项随机、双盲、安慰剂对照试验。
J Affect Disord. 2019 Jan 15;243:516-524. doi: 10.1016/j.jad.2018.09.037. Epub 2018 Sep 17.
7
Ketamine Use for Suicidal Ideation in the General Hospital: Case Report and Short Review.氯胺酮用于综合医院自杀观念:病例报告及简短综述
J Psychiatr Pract. 2018 Jan;24(1):56-59. doi: 10.1097/PRA.0000000000000282.
8
Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial.氯胺酮用于快速降低自杀意念:一项随机对照试验。
Psychol Med. 2015 Dec;45(16):3571-80. doi: 10.1017/S0033291715001506. Epub 2015 Aug 12.
9
Ketamine and suicidal ideation in depression: Jumping the gun?氯胺酮与抑郁症中的自杀意念:操之过急?
Pharmacol Res. 2015 Sep;99:23-35. doi: 10.1016/j.phrs.2015.05.003. Epub 2015 May 15.
10
Suicide by hanging under the influence of ketamine and ethanol.氯胺酮和乙醇影响下的自缢。
Forensic Sci Int. 2010 Oct 10;202(1-3):e23-7. doi: 10.1016/j.forsciint.2010.04.047. Epub 2010 May 26.

本文引用的文献

1
A Double-Blinded, Randomized, Placebo-Controlled Sub-Dissociative Dose Ketamine Pilot Study in the Treatment of Acute Depression and Suicidality in a Military Emergency Department Setting.一项在军事急诊科环境中进行的双盲、随机、安慰剂对照亚解离剂量氯胺酮治疗急性抑郁和自杀倾向的初步研究。
Mil Med. 2016 Oct;181(10):1195-1199. doi: 10.7205/MILMED-D-15-00431.
2
Role of ketamine for analgesia in adults and children.氯胺酮在成人和儿童镇痛中的作用。
J Anaesthesiol Clin Pharmacol. 2016 Jul-Sep;32(3):298-306. doi: 10.4103/0970-9185.168149.
3
WHITHER KETAMINE AS AN ANTIDEPRESSANT: PANACEA OR TOXIN?氯胺酮作为一种抗抑郁药的未来走向:万灵药还是毒药?
Depress Anxiety. 2016 Aug;33(8):685-8. doi: 10.1002/da.22535.
4
NMDAR inhibition-independent antidepressant actions of ketamine metabolites.氯胺酮代谢物的非NMDAR抑制依赖性抗抑郁作用。
Nature. 2016 May 26;533(7604):481-6. doi: 10.1038/nature17998. Epub 2016 May 4.
5
KETAMINE: A POTENTIAL RAPID-ACTING ANTISUICIDAL AGENT?氯胺酮:一种潜在的速效抗自杀药物?
Depress Anxiety. 2016 Aug;33(8):711-7. doi: 10.1002/da.22498. Epub 2016 Apr 15.
6
Practical application of the neuroregenerative properties of ketamine: real world treatment experience.氯胺酮神经再生特性的实际应用:真实世界的治疗经验。
Neural Regen Res. 2016 Feb;11(2):195-200. doi: 10.4103/1673-5374.177708.
7
Single i.v. ketamine augmentation of newly initiated escitalopram for major depression: results from a randomized, placebo-controlled 4-week study.单次静脉注射氯胺酮增强新起始的艾司西酞普兰治疗重度抑郁症的疗效:一项随机、安慰剂对照的4周研究结果
Psychol Med. 2016 Feb;46(3):623-35. doi: 10.1017/S0033291715002159. Epub 2015 Oct 19.
8
Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression.氯胺酮和其他 NMDA 拮抗剂:抑郁症的早期临床试验和可能的机制。
Am J Psychiatry. 2015 Oct;172(10):950-66. doi: 10.1176/appi.ajp.2015.15040465.
9
Does lithium reduce acute suicidal ideation and behavior? A protocol for a randomized, placebo-controlled multicenter trial of lithium plus Treatment As Usual (TAU) in patients with suicidal major depressive episode.锂能否降低急性自杀意念和行为?一项锂联合治疗常规(TAU)治疗有自杀意念的重性抑郁发作患者的随机、安慰剂对照、多中心试验方案。
BMC Psychiatry. 2015 May 19;15:117. doi: 10.1186/s12888-015-0499-5.
10
Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder.氯胺酮对难治性重度抑郁症患者情绪感知神经反应的调节作用
Transl Psychiatry. 2015 Feb 17;5(2):e509. doi: 10.1038/tp.2015.10.