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加巴喷丁在急性酒精戒断管理中的应用。

Gabapentin Use in Acute Alcohol Withdrawal Management.

作者信息

Wilming Christopher, Alford Mariah, Klaus Lynnette

机构信息

is a PGY-1 Pharmacy Practice Resident, is a General Medicine Clinical Pharmacist, and is an Associate Chief of Acute Care Pharmacy and PGY-1 Acute Care Residency Director, all at the VA Portland Health Care System in Oregon.

出版信息

Fed Pract. 2018 Mar;35(3):40-46.

PMID:30766348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6368058/
Abstract

Gabapentin's anxiolytic and sedative properties along with its overall safety profile suggest that it may be a viable adjuvant to lorazepam in the management of acute alcohol withdrawal.

摘要

加巴喷丁的抗焦虑和镇静特性及其总体安全性表明，在急性酒精戒断的管理中，它可能是劳拉西泮的一种可行辅助药物。

相似文献

1
Gabapentin Use in Acute Alcohol Withdrawal Management.加巴喷丁在急性酒精戒断管理中的应用。
Fed Pract. 2018 Mar;35(3):40-46.
2
Gabapentin's acute effect on mood profile -- a controlled study on patients with alcohol withdrawal.加巴喷丁对情绪状态的急性影响——一项关于酒精戒断患者的对照研究。
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):434-8. doi: 10.1016/j.pnpbp.2006.11.006. Epub 2006 Dec 18.
3
High-Dose Gabapentin for the Treatment of Severe Alcohol Withdrawal Syndrome: A Retrospective Cohort Analysis.高剂量加巴喷丁治疗严重酒精戒断综合征：回顾性队列分析。
Pharmacotherapy. 2019 Sep;39(9):881-888. doi: 10.1002/phar.2309. Epub 2019 Jul 22.
4
Retrospective analysis of a gabapentin high dose taper compared to lorazepam in acute inpatient alcohol withdrawal.回顾性分析高剂量加巴喷丁逐渐停药与劳拉西泮治疗急性住院酒精戒断的疗效比较。
Am J Drug Alcohol Abuse. 2019;45(4):385-391. doi: 10.1080/00952990.2019.1602136. Epub 2019 Apr 16.
5
Gabapentin for alcohol use disorder: A good option, or cause for concern?加巴喷丁治疗酒精使用障碍：好的选择，还是令人担忧的因素？
Cleve Clin J Med. 2019 Dec;86(12):815-823. doi: 10.3949/ccjm.86a.18128.
6
Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentin.自我报告的睡眠、嗜睡及反复酒精戒断：劳拉西泮与加巴喷丁的随机、双盲、对照比较
J Clin Sleep Med. 2007 Feb 15;3(1):24-32.
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A randomized, open-label, controlled trial of gabapentin and phenobarbital in the treatment of alcohol withdrawal.加巴喷丁与苯巴比妥治疗酒精戒断的随机、开放标签、对照试验。
Am J Addict. 2006 Jan-Feb;15(1):76-84. doi: 10.1080/10550490500419110.
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Anticonvulsants for the treatment of alcohol withdrawal syndrome and alcohol use disorders.用于治疗酒精戒断综合征和酒精使用障碍的抗惊厥药。
CNS Drugs. 2015 Apr;29(4):293-311. doi: 10.1007/s40263-015-0240-4.
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The role of gabapentin in the management of alcohol withdrawal and dependence.加巴喷丁在酒精戒断和成瘾管理中的作用。
Ann Pharmacother. 2015 Aug;49(8):897-906. doi: 10.1177/1060028015585849. Epub 2015 May 12.
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Gabapentin: Change is in the Wind.加巴喷丁：变革在即。
Sr Care Pharm. 2019 Sep 1;34(8):490-498.

引用本文的文献

1
Retrospective Analysis of Gabapentin for Alcohol Withdrawal in the Hospital Setting: The Mayo Clinic Experience.加巴喷丁用于医院环境中酒精戒断的回顾性分析：梅奥诊所经验
Mayo Clin Proc Innov Qual Outcomes. 2020 Aug 19;4(5):542-549. doi: 10.1016/j.mayocpiqo.2020.06.002. eCollection 2020 Oct.

本文引用的文献

1
The role of gabapentin in the management of alcohol withdrawal and dependence.加巴喷丁在酒精戒断和成瘾管理中的作用。
Ann Pharmacother. 2015 Aug;49(8):897-906. doi: 10.1177/1060028015585849. Epub 2015 May 12.
2
Contribution of excessive alcohol consumption to deaths and years of potential life lost in the United States.过度饮酒对美国死亡人数及潜在寿命损失年数的影响。
Prev Chronic Dis. 2014 Jun 26;11:E109. doi: 10.5888/pcd11.130293.
3
Alcohol withdrawal syndrome.酒精戒断综合征。
Crit Care Clin. 2012 Oct;28(4):549-85. doi: 10.1016/j.ccc.2012.07.004.
4
The association between substance use disorders and mortality among a cohort of Veterans with posttraumatic stress disorder: variation by age cohort and mortality type.创伤后应激障碍退伍军人队列中物质使用障碍与死亡率之间的关联：按年龄队列和死亡类型的差异。
Drug Alcohol Depend. 2013 Feb 1;128(1-2):98-103. doi: 10.1016/j.drugalcdep.2012.08.015. Epub 2012 Sep 11.
5
Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome.药物干预治疗酒精戒断综合征的疗效与安全性。
Cochrane Database Syst Rev. 2011 Jun 15;2011(6):CD008537. doi: 10.1002/14651858.CD008537.pub2.
6
Alcohol withdrawal syndromes in the intensive care unit.重症监护病房中的酒精戒断综合征。
Crit Care Med. 2010 Sep;38(9 Suppl):S494-501. doi: 10.1097/CCM.0b013e3181ec5412.
7
An open trial of gabapentin in acute alcohol withdrawal using an oral loading protocol.采用口服负荷量方案的加巴喷丁治疗急性酒精戒断的开放性试验。
Alcohol Alcohol. 2010 Mar-Apr;45(2):143-5. doi: 10.1093/alcalc/agp085. Epub 2009 Dec 17.
8
A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal.加巴喷丁与劳拉西泮治疗酒精戒断的双盲试验。
Alcohol Clin Exp Res. 2009 Sep;33(9):1582-8. doi: 10.1111/j.1530-0277.2009.00986.x. Epub 2009 May 26.
9
A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens.递增剂量给予苯二氮䓬类药物和苯巴比妥的策略可减少震颤谵妄患者对机械通气的需求。
Crit Care Med. 2007 Mar;35(3):724-30. doi: 10.1097/01.CCM.0000256841.28351.80.
10
Benzodiazepines for alcohol withdrawal.用于酒精戒断的苯二氮䓬类药物。
Cochrane Database Syst Rev. 2005 Jul 20(3):CD005063. doi: 10.1002/14651858.CD005063.pub2.