Mariani John J, Rosenthal Richard N, Tross Susan, Singh Prameet, Anand Om P
Department of Psychiatry, Division on Substance Abuse, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Am J Addict. 2006 Jan-Feb;15(1):76-84. doi: 10.1080/10550490500419110.
Gabapentin was compared with phenobarbital for the treatment of alcohol withdrawal in a randomized, open-label, controlled trial in 27 inpatients. There were no significant differences in the proportion of treatment completers between treatment groups or the proportion of patients in each group requiring rescue medication for breakthrough signs and symptoms of alcohol withdrawal. There were no significant treatment differences in withdrawal symptoms or psychological distress, nor were there serious adverse events. These findings suggest that gabapentin may be as effective as phenobarbital in the treatment of alcohol withdrawal. Given gabapentin's favorable pharmacokinetic profile, further study of its effectiveness in treating alcohol withdrawal is warranted.
在一项针对27名住院患者的随机、开放标签、对照试验中，将加巴喷丁与苯巴比妥用于治疗酒精戒断进行了比较。治疗组之间的治疗完成者比例或每组中因酒精戒断的突破性体征和症状而需要急救药物的患者比例没有显著差异。在戒断症状或心理困扰方面没有显著的治疗差异，也没有严重不良事件。这些发现表明，加巴喷丁在治疗酒精戒断方面可能与苯巴比妥一样有效。鉴于加巴喷丁良好的药代动力学特性，有必要进一步研究其治疗酒精戒断的有效性。
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