Balın Şafak Özer, Tartar Ayşe Sağmak, Akbulut Ayhan
Fırat University Medical Faculty Hospital, Department of Infectious Disease, Elazig, 23000, Turkey.
Afr Health Sci. 2018 Dec;18(4):988-994. doi: 10.4314/ahs.v18i4.19.
Brucellosis is a zoonosis that affects several systems, especially with the osteoarticular involvement.
This study aims to compare the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), mean platelet volume (MPV) and red blood cell distribution (RDW) in patients with the osteoarticular involvement and those with non-localised brucellosis and evaluate their predictive value for the diagnosis of osteoarticular brucellosis.
We enrolled 140 patients with brucellosis, 70 with the osteoarticular involvement and 70 without any localised involvement. We collected patients' data retrospectively and compared haematological parameters between both groups. In patients with osteoarticular brucellosis, a correlation of the NLR with the ESR and CRP and correlation of the MLR with the ESR and CRP were assessed. Furthermore, the predictive performance of the ESR, CRP, NLR and MLR on the osteoarticular involvement was evaluated.
The NLR, MLR, ESR, CRP, neutrophil and monocyte levels were higher in the patient group than the control group.
The NLR, MLR, ESR and CRP are useful parameters to estimate the clinical course of patients with brucellosis, and the NLR and MLR are alternative to inflammatory markers in the osteoarticular involvement.
布鲁氏菌病是一种人畜共患病，可累及多个系统，尤其是骨关节受累。
本研究旨在比较骨关节受累患者与非局限性布鲁氏菌病患者的中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、单核细胞/淋巴细胞比值（MLR）、C反应蛋白（CRP）、红细胞沉降率（ESR）、平均血小板体积（MPV）和红细胞分布宽度（RDW），并评估它们对骨关节型布鲁氏菌病诊断的预测价值。
我们纳入了140例布鲁氏菌病患者，其中70例有骨关节受累，70例无任何局限性受累。我们回顾性收集患者数据，并比较两组之间的血液学参数。在骨关节型布鲁氏菌病患者中，评估NLR与ESR和CRP的相关性以及MLR与ESR和CRP的相关性。此外，评估ESR、CRP、NLR和MLR对骨关节受累的预测性能。
患者组的NLR、MLR、ESR、CRP、中性粒细胞和单核细胞水平高于对照组。
NLR、MLR、ESR和CRP是评估布鲁氏菌病患者临床病程的有用参数，NLR和MLR可作为骨关节受累时炎症标志物的替代指标。
