Togan Turhan, Narci Huseyin, Turan Hale, Ciftci Ozgur, Kursun Ebru, Arslan Hande
Department of Infectious Diseases and Clinical Microbiology, Baskent University, Ankara, Turkey.
Department of Emergency Medicine, Baskent University, Ankara, Turkey.
Jundishapur J Microbiol. 2015 Feb 20;8(2):e20039. doi: 10.5812/jjm.20039. eCollection 2015 Feb.
Brucellosis is an inflammatory disease which may infect any organs or systems in the body. Mean Platelet Volume (MPV) is one of the most frequently used surrogate markers of platelet function. It reveals the presence of disease activity in many inflammatory diseases. Red blood cell distribution width (RDW) is a parameter that measures variation in red blood cell size or red blood cell volume. Its predictive value approves inflammatory and infectious diseases.
The current study aimed to determine the assessment levels of red blood cell distribution in cases with acute brucellosis.
The current study investigated whether MPV and RDW played any roles in acute brucellosis diagnosis. The study was conducted from 2008 to 2014 through prospective examination of the inflammatory markers found in adult patients with acute brucellosis.
The follow-up within the year after treatment was examined. The values of age, gender, leukocyte count, C-reactive protein, RDW and MPV were recorded. The study included 351 subjects, 250 of them in the acute brucellosis group and 101 in the control group. The mean MPV levels were 7.64 ± 1.30 fL, and 7.67 ± 1.29 fL in the acute brucellosis and control groups, respectively (P > 0.05). The mean CRP levels were 32.57 ± 53.20 mg/dL, and 4.81 ± 4.89 mg/dL in the acute brucellosis and control groups, respectively (P < 0.05). There was no statistically significant difference between the two groups regarding the RDW level and the mean leukocyte count (P > 0.05).
While the CRP value was in patients with acute brucellosis in the current study, the MPV, RDW and leukocyte counts were within the normal range. CRP value remains the most valuable inflammatory marker in cases of acute brucellosis.
布鲁氏菌病是一种炎症性疾病，可感染身体的任何器官或系统。平均血小板体积（MPV）是最常用的血小板功能替代指标之一。它揭示了许多炎症性疾病中疾病活动的存在。红细胞分布宽度（RDW）是衡量红细胞大小或红细胞体积变化的参数。其预测价值在炎症和感染性疾病中得到认可。
本研究旨在确定急性布鲁氏菌病患者红细胞分布的评估水平。
本研究调查了MPV和RDW在急性布鲁氏菌病诊断中是否起作用。该研究于2008年至2014年通过对成年急性布鲁氏菌病患者发现的炎症标志物进行前瞻性检查来进行。
对治疗后一年内的随访情况进行了检查。记录了年龄、性别、白细胞计数、C反应蛋白、RDW和MPV的值。该研究包括351名受试者，其中250名在急性布鲁氏菌病组，101名在对照组。急性布鲁氏菌病组和对照组的平均MPV水平分别为7.64±1.30 fL和7.67±1.29 fL（P>0.05）。急性布鲁氏菌病组和对照组的平均CRP水平分别为32.57±53.20 mg/dL和4.81±4.89 mg/dL（P<0.05）。两组在RDW水平和平均白细胞计数方面无统计学显著差异（P>0.05）。
在本研究中，急性布鲁氏菌病患者的CRP值异常，而MPV、RDW和白细胞计数在正常范围内。CRP值仍然是急性布鲁氏菌病病例中最有价值的炎症标志物。
