尼日利亚纽维市纳姆迪·阿齐克韦大学教学医院镰状细胞病患者与对照组中糖类抗原19-9的对比研究。
comparative study of carbohydrate antigen 19-9 in sickle cell disease subjects and controls in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
作者信息
Manafa Patrick, Okocha Chide, Nwogho Benedict, Aneke John, Okpara Paul Smith Davis, Lbeh Nancy, Chukwuma George, Manafa Vera, Nwane Ejike
机构信息
Medical laboratory Science department, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State Nigeria.
Haematology Department, Nnamdi Azikiwe University Teaching Hospital, PMB 5025, Nnewi, Anambra State, Nigeria.
出版信息
Afr Health Sci. 2018 Dec;18(4):1003-1009. doi: 10.4314/ahs.v18i4.21.
BACKGROUND
Sickle cell disease is characterized by chronic complications that affect almost all body organs. Pancreatic disease is rare in SCD. CA 19-9 is a non-specific surrogate marker for pancreatic disease especially carcinoma. CA 19-9 levels have not been evaluated in SCD patients in our environment.
OBJECTIVES
The study aimed to compare the levels of CA 19-9 in homozygous sickle cell disease subjects in steady state with those of (Hb AS) and normal healthy subjects (Hb AA).
METHOD
Seventy nine subjects including 39 Hb SS, 19 Hb AS and 21 Hb AA subjects were recruited in a cross-sectional study in Nnamdi Azikiwe University and Teaching Hospital. Haemoglobin genotype and CA 19-9 estimation were done using Hb electrophoresis and enzyme linked immunosorbent assay respectively. Data was analyzed with IBM SPSS 21. P value was set at 0.05.
RESULT
The mean CA 19-9 (U/ml) level in Hb SS, Hb AS and Hb AA were 13.6 ± 7.6, 15.3 ± 9.9, and 20.0 ± 15.9 respectively. [Reference value <37U/ml] CA 19-9 was significantly lower in Hb SS compared to Hb AA subjects (p = 0.035).
CONCLUSION
Low levels of CA 19-9 in Hb SS may suggest reduced pancreatic disorders in SCA.
背景
镰状细胞病的特征是存在影响几乎所有身体器官的慢性并发症。胰腺疾病在镰状细胞病中较为罕见。CA 19-9是胰腺疾病尤其是胰腺癌的非特异性替代标志物。在我们的环境中，尚未对镰状细胞病患者的CA 19-9水平进行评估。
目的
本研究旨在比较稳态下纯合镰状细胞病患者与（血红蛋白AS）和正常健康受试者（血红蛋白AA）的CA 19-9水平。
方法
在纳姆迪·阿齐克韦大学及其教学医院进行的一项横断面研究中，招募了79名受试者，包括39名血红蛋白SS、19名血红蛋白AS和21名血红蛋白AA受试者。分别使用血红蛋白电泳和酶联免疫吸附测定法进行血红蛋白基因型和CA 19-9测定。数据用IBM SPSS 21进行分析。P值设定为0.05。
结果
血红蛋白SS、血红蛋白AS和血红蛋白AA的平均CA 19-9（U/ml）水平分别为13.6±7.6、15.3±9.9和20.0±15.9。[参考值<37U/ml]与血红蛋白AA受试者相比，血红蛋白SS中的CA 19-9显著降低（p = 0.035）。
结论
血红蛋白SS中CA 19-9水平较低可能表明镰状细胞贫血患者的胰腺疾病减少。
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