Reid Robert L, Magee Bryden A
Division of Reproductive Endocrinology and Infertility, Queen's University, Kingston, Ontario K7L 4 V1 Canada.
Womens Midlife Health. 2015 Oct 5;1:7. doi: 10.1186/s40695-015-0008-5. eCollection 2015.
Canada's Generation X is now entering the menopausal transition and pursuing effective therapy for bothersome vasomotor symptoms. They do so at a time when confusion about the safe and appropriate use of menopausal hormone therapy (MHT) has never been greater. Misplaced fears among women and their health care providers about MHT have, in many circumstances, led them to abandon this most effective therapy. This review discusses the physiology of the menopausal transition, the nature of symptoms related to withdrawal of ovarian estrogen production, and the potential benefits and risks of MHT. It is now clear that for most recently menopausal women the benefits of MHT outweigh the risks. The rationale for choosing different dosages, formulations, and regimens is reviewed.
加拿大的X一代女性目前正步入更年期过渡阶段，并在寻求有效疗法来缓解令人困扰的血管舒缩症状。她们这么做的时候，人们对更年期激素疗法（MHT）安全且恰当使用的困惑达到了前所未有的程度。在许多情况下，女性及其医疗保健提供者对MHT的无端恐惧导致他们放弃了这种最有效的疗法。本综述讨论了更年期过渡的生理学、与卵巢雌激素分泌减少相关症状的性质，以及MHT的潜在益处和风险。现在很清楚，对于大多数刚进入更年期的女性来说，MHT的益处大于风险。本文还综述了选择不同剂量、剂型和给药方案的理论依据。
