年龄和种族对职业女性儿茶酚胺和皮质醇昼夜变化的影响。

The effects of age and ethnicity on the circadian variation of catecholamines and cortisol in employed women.

作者信息

James Gary D

机构信息

Department of Anthropology, Binghamton University-SUNY, Binghamton, NY 13902 USA.

出版信息

Womens Midlife Health. 2018 Jun 28;4:10. doi: 10.1186/s40695-018-0040-3. eCollection 2018.

DOI:10.1186/s40695-018-0040-3

PMID:30766720

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6298005/

Abstract

BACKGROUND

Women employed outside the home in urban settings must adapt to changing circadian microenvironments. The pattern and extent of vasoactive hormone responses to these changes may depend upon age and ethnic background. The purpose of this study was to evaluate the effects of age and ethnicity on the circadian variation of urinary norepinephrine, epinephrine, and cortisol excretion across work, home and sleep microenvironments.

METHODS

The subjects of the study were 95 women (38 European-American, age = 35.4 ± 7.4; 28 African-American, age = 33.4 ± 7.9; 12 Asian-American, age = 36.7 ± 9.3 and 17 Hispanic-American age = 31.6 ± 10.9) employed as secretaries, lab technicians or office supervisors in New York City. Variation in the hormones across the microenvironments was evaluated using repeated measures ANCOVA with age group (18-29.9; 30-39.9; 40-49.9) and ethnicity as fixed factors.

RESULTS

The results show that for norepinephrine and epinephrine, work excretion rates are substantially higher than sleep rates ( < .001), and for epinephrine home rates were higher than sleep rates ( < .001). Work and sleep cortisol excretion rates were also significantly higher than the rate at home, consistent with cortisol's circadian rhythm. ( < .002). Women in their twenties had substantially lower norepinephrine excretion rates than women over 30 ( < .04). There were also ethnic differences in norepinephrine ( < .04) and epinephrine ( = .11) output with Asian-American women having the lowest and African-American women having the highest rates. This variation is likely related to the ethnic variation in weight. There was no significant variation in cortisol excretion with age or ethnicity.

CONCLUSION

The circadian rates of norepinephrine excretion differ by age and that of both catecholamines differ by ethnicity among women working outside the home. It is speculated that the age variation in norepinephrine may contribute to the development of vasomotor symptoms.

摘要

背景

在城市环境中外出工作的女性必须适应不断变化的昼夜微环境。血管活性激素对这些变化的反应模式和程度可能取决于年龄和种族背景。本研究的目的是评估年龄和种族对跨工作、家庭和睡眠微环境的尿去甲肾上腺素、肾上腺素和皮质醇排泄昼夜变化的影响。

方法

本研究的受试者为95名女性（38名欧美裔，年龄=35.4±7.4；28名非裔美国人，年龄=33.4±7.9；12名亚裔美国人，年龄=36.7±9.3；17名西班牙裔美国人，年龄=31.6±10.9），她们在纽约市担任秘书、实验室技术员或办公室主管。使用重复测量协方差分析评估各微环境中激素的变化，年龄组（18 - 29.9；30 - 39.9；40 - 49.9）和种族作为固定因素。

结果

结果表明，对于去甲肾上腺素和肾上腺素，工作时的排泄率显著高于睡眠时（<0.001），对于肾上腺素，在家时的排泄率高于睡眠时（<0.001）。工作和睡眠时的皮质醇排泄率也显著高于在家时，这与皮质醇的昼夜节律一致（<0.002）。二十多岁的女性去甲肾上腺素排泄率显著低于30岁以上的女性（<0.04）。去甲肾上腺素（<0.04）和肾上腺素（=0.11）的输出也存在种族差异，亚裔美国女性的排泄率最低，非裔美国女性的排泄率最高。这种差异可能与体重的种族差异有关。皮质醇排泄在年龄或种族方面没有显著差异。