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成人皮肌炎的生物标志物:辅助诊断和预测临床结局的工具。

Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome.

机构信息

Dermatology Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

INSERM U976, Laboratory of Oncodermatology, Immunology, and Cutaneous Stem Cells, Hôpital Saint-Louis, Paris, France.

出版信息

J Immunol Res. 2019 Jan 14;2019:9141420. doi: 10.1155/2019/9141420. eCollection 2019.

Abstract

Dermatomyositis pathophysiology is complex. In recent years, medical research has identified molecules associated with disease activity. Besides providing insights into the driving mechanisms of dermatomyositis, these findings could provide potential biomarkers. Activity markers can be used to monitor disease activity in clinical trials and may also be useful in daily practice. This article reviews molecules that could be used as biomarkers for diagnosis and monitoring dermatomyositis disease activity.

摘要

皮肌炎的发病机制较为复杂。近年来,医学研究已经发现了与疾病活动相关的分子。这些发现除了为皮肌炎的驱动机制提供了深入了解,还可能提供潜在的生物标志物。活性标志物可用于临床试验中监测疾病活动,在日常实践中可能也有一定的作用。本文综述了可作为皮肌炎疾病活动诊断和监测生物标志物的分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9680/6350546/81c667c7d5d5/JIR2019-9141420.001.jpg

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