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在世卫组织非洲区域的儿童疫苗接种计划中引入含麻疹疫苗的第二剂次——经验教训

Introduction of the Second Dose of Measles Containing Vaccine in the Childhood Vaccination Programs Within the WHO Africa Region - Lessons Learnt.

作者信息

Masresha Balcha G, Luce Richard, Okeibunor Joseph, Shibeshi Messeret Eshetu, Kamadjeu Raoul, Fall Amadou

机构信息

WHO Regional Office for Africa. Brazzaville, Congo.

WHO Inter-country Support Team for Central Africa. Libreville, Gabon.

出版信息

J Immunol Sci. 2018 Jul 28;Suppl:113-121.

PMID:30766972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6372060/
Abstract

BACKGROUND

WHO recommends all countries to include a second routine dose of measles containing vaccine (MCV2) in their national routine vaccination schedules regardless of the level of coverage with the first routine dose of measles containing vaccine (MCV1). As of Dec 2016, 26 countries in the African Region have introduced MCV2.

METHODS

We reviewed the WHO UNICEF coverage estimates for MCV1 and MCV2 in these countries, and the reports of the post introduction evaluation of MCV2 from 11 countries.

RESULTS

Twenty three countries have WHO/UNICEF estimates of MCV2 coverage available in 2015. Of these, 2 countries have coverage of ≥ 95% for both MCV1 and MCV2 while 5 countries have coverage of > 80% for both doses. Dropout rates of >20% MCV1 - MCV2 exist in 12 countries. Post-MCV2 introduction evaluations done in 11 countries from 2012 to 2015 showed that inadequate health worker training, insufficient sensitization and awareness generation among parents and suboptimal dose recording practices were common programmatic weaknesses that contributed to the low MCV2 coverage in these countries.

CONCLUSION

MCV2 coverage remains low as reflected in large drop-out rates in most countries. Higher MCV2 coverage is necessary to sustainably achieve the regional measles elimination goal. National immunization programs must improve implementation of MCV2 using the standard introduction and evaluation guidelines available for EPI program planning.

摘要

背景

世界卫生组织建议所有国家在其国家常规疫苗接种计划中纳入第二剂含麻疹疫苗(MCV2),无论第一剂含麻疹疫苗(MCV1)的接种覆盖率如何。截至2016年12月,非洲区域有26个国家引入了MCV2。

方法

我们审查了世界卫生组织/联合国儿童基金会对这些国家MCV1和MCV2的接种覆盖率估计,以及11个国家引入MCV2后的评估报告。

结果

2015年有23个国家有世界卫生组织/联合国儿童基金会对MCV2接种覆盖率的估计。其中,2个国家MCV1和MCV2的接种覆盖率均≥95%,5个国家两剂次的接种覆盖率均>80%。12个国家MCV1至MCV2的接种率下降幅度>20%。2012年至2015年在11个国家进行的MCV2引入后评估表明,卫生工作者培训不足、对家长的宣传和意识提高不够以及剂量记录做法欠佳是常见的项目弱点,导致这些国家MCV2接种覆盖率较低。

结论

如大多数国家的高接种率下降所反映的,MCV2接种覆盖率仍然较低。为可持续实现区域消除麻疹目标,需要更高的MCV2接种覆盖率。国家免疫规划必须利用可用于扩大免疫规划项目规划的标准引入和评估指南,改进MCV2的实施。

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