de Zoysa A P, Herath P R, Abhayawardana T A, Padmalal U K, Mendis K N
Open University of Sri Lanka, Nugegoda.
Trans R Soc Trop Med Hyg. 1988;82(4):548-53. doi: 10.1016/0035-9203(88)90500-7.
Natural Plasmodium vivax malaria infections in man evoke anti-gamete transmission blocking antibodies which influence the infectivity of malaria patients to the vector mosquito. In this study, entomological, immunological and parasitological data obtained through the monitoring of an epidemic of human vivax malaria in Sri Lanka were used in a mathematical simulation to assess the effect of naturally induced transmission blocking immunity on malaria transmission. A mathematical model to describe malaria transmission accounting for transmission blocking immunity was developed from the basic differential equations originally stated by R. Ross and the epidemic was simulated using the available data. An attempt was made to predict the monthly malaria incidence by means of the mathematical simulation, with and without accounting for transmission blocking immunity. A plausible mathematical solution of the epidemic could be obtained when transmission blocking immunity was accounted for, and it was not possible to obtain such a plausible solution in the absence of immunity. Thus, the postulated occurrence of transmission blocking immunity was essential to describe adequately this malaria epidemic, indicating that, at least in epidemic situations, naturally occurring transmission blocking immunity has a controlling influence on malaria incidence.
人类自然感染间日疟原虫会产生抗配子传播阻断抗体，这些抗体影响疟疾患者对媒介蚊子的感染性。在本研究中，通过监测斯里兰卡间日疟流行所获得的昆虫学、免疫学和寄生虫学数据被用于数学模拟，以评估自然诱导的传播阻断免疫对疟疾传播的影响。从R. Ross最初提出的基本微分方程出发，建立了一个描述考虑传播阻断免疫的疟疾传播的数学模型，并利用现有数据对该流行进行了模拟。尝试通过数学模拟预测有无传播阻断免疫情况下的每月疟疾发病率。当考虑传播阻断免疫时，可以得到该流行的一个合理数学解，而在没有免疫的情况下则无法得到这样一个合理的解。因此，假定的传播阻断免疫的发生对于充分描述此次疟疾流行至关重要，这表明，至少在流行情况下，自然产生的传播阻断免疫对疟疾发病率具有控制作用。
