Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
Br J Pharmacol. 2019 May;176(9):1173-1189. doi: 10.1111/bph.14623. Epub 2019 Mar 27.
Parkinson's disease (PD) is a progressive movement disorder resulting primarily from loss of nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein aggregates, and evidence suggests that aberrant protein deposition in dopaminergic neurons could be related to the dysregulation of the lysosomal autophagy pathway. The therapeutic potential of autophagy modulators has been reported in experimental models of PD. Trehalose is a natural disaccharide that has been considered as a new candidate for the treatment of neurodegenerative diseases. It has a chaperone-like activity, prevents protein misfolding or aggregation, and by promoting autophagy, contributes to the removal of accumulated proteins. In this review, we briefly summarize the role of aberrant autophagy in PD and the underlying mechanisms that lead to the development of this disease. We also discuss reports that used trehalose to counteract the neurotoxicity in PD, focusing particularly on the autophagy promoting, protein stabilization, and anti-neuroinflammatory effects of trehalose.
帕金森病（PD）是一种进行性运动障碍，主要由黑质纹状体多巴胺能神经元丧失引起。PD 的特征是蛋白质聚集体的积累，有证据表明，多巴胺能神经元中异常的蛋白质沉积可能与溶酶体自噬途径的失调有关。自噬调节剂在 PD 的实验模型中显示出治疗潜力。海藻糖是一种天然二糖，已被认为是治疗神经退行性疾病的新候选药物。它具有分子伴侣样活性，可防止蛋白质错误折叠或聚集，并通过促进自噬有助于清除积累的蛋白质。在这篇综述中，我们简要总结了异常自噬在 PD 中的作用以及导致这种疾病发展的潜在机制。我们还讨论了使用海藻糖来对抗 PD 神经毒性的报告，特别关注海藻糖的自噬促进、蛋白质稳定和抗神经炎症作用。
