a Department of Pediatrics , Maasstad Hospital , Rotterdam , The Netherlands.
b Department of Paediatric Gastroenterology , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.
Expert Rev Clin Pharmacol. 2019 Apr;12(4):355-361. doi: 10.1080/17512433.2019.1582330. Epub 2019 Feb 26.
The onset of inflammatory bowel disease (IBD) in children is rising. Current treatment options are based on immunomodulatory therapy. Alternative treatment options are upcoming since they appear to be effective in individual patients. Cannabis might relief IBD symptoms in these cases and improve quality of life. Recent evidence suggests a potential anti-inflammatory effect of cannabis. Areas covered: This review presents an overview of recent literature on the use of cannabis in IBD focussing on pediatric IBD patients. Background information on the role of the endocannabinoid system within the gastrointestinal tract is presented. Other modalities of cannabis and its purified ingredients will be discussed as well, with attention to its applicability in children with IBD. Expert opinion: More research is needed on the efficacy and safety of cannabis in pediatric IBD. Studies are well underway, but until then the use of cannabis in pediatric IBD cannot be recommended.
炎症性肠病（IBD）在儿童中的发病正在上升。目前的治疗选择基于免疫调节疗法。由于在个别患者中似乎有效，因此即将出现替代治疗选择。在这些情况下，大麻可能会缓解 IBD 症状并提高生活质量。最近的证据表明大麻具有潜在的抗炎作用。
本文综述了最近关于大麻在 IBD 中应用的文献，重点是儿科 IBD 患者。介绍了内源性大麻素系统在胃肠道中的作用背景信息。还讨论了大麻的其他形式及其纯化成分，以及其在患有 IBD 的儿童中的适用性。
需要对大麻在儿科 IBD 中的疗效和安全性进行更多研究。研究正在进行中，但在那之前，不能推荐大麻在儿科 IBD 中的使用。
