Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Department of Dermatology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
J Dermatol. 2019 May;46(5):436-439. doi: 10.1111/1346-8138.14814. Epub 2019 Feb 15.
Pigmented Bowen's disease (pBD) is a subtype of Bowen's disease, which presents clinically as a well-circumscribed, hyperpigmented plaque. Its clinical manifestations are not fully characterized, and differential diagnoses include various pigmented skin lesions. Dermoscopy could be useful for the diagnosis, although nothing has been reported on the dermoscopic features of clonal-type pBD. We herein report a first case of clonal-type pBD on the sole and its dermoscopic features. Dermoscopy showed brown to blue-gray dots/globules and focally anastomosing lines on the non-weight-bearing area, while the weight-bearing area had a brown to blue-gray fibrillar-like pattern. To investigate the relationship between dermoscopy and histopathology, we focused on the melanin distribution in the horny layer of the epidermis, and used vertical dermoscopy observation. We investigated the relationship between dermoscopy and pathology by melanin depth estimation using a color lightness value.
色素性 Bowen 病（pBD）是 Bowen 病的一个亚型，临床上表现为边界清楚的色素斑。其临床表现尚未完全明确，鉴别诊断包括各种色素性皮肤病变。皮肤镜检查有助于诊断，尽管尚未有关于克隆型 pBD 的皮肤镜特征的报道。我们在此报告首例足底克隆型 pBD 及其皮肤镜特征。皮肤镜检查显示非承重区的棕色至蓝灰色点状/球状和局灶性吻合线，而承重区则呈棕色至蓝灰色纤维状模式。为了研究皮肤镜与组织病理学之间的关系，我们重点关注表皮角质层中的黑色素分布，并采用垂直皮肤镜观察。我们通过颜色亮度值估计黑色素深度来研究皮肤镜与病理学之间的关系。
