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垂直离体皮肤镜检查在恶性皮肤病变评估中的应用

Vertical Ex Vivo Dermoscopy in Assessment of Malignant Skin Lesions.

作者信息

Popadić Mirjana, Brasanac Dimitrije, Milošev Danijela, Ravić Nikolić Ana, Mitrović Slobodanka

机构信息

Department of Dermatovenerology, Faculty of Medicine, University of Belgrade, Clinic of Dermatovenereology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.

Institute of Pathology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.

出版信息

Biomedicines. 2024 Jul 28;12(8):1683. doi: 10.3390/biomedicines12081683.

DOI:10.3390/biomedicines12081683
PMID:39200148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11351155/
Abstract

The role of vertical ex vivo dermoscopy relevant to clinical diagnosis has not been investigated yet. Study objectives were defining, describing, and determining the importance of the structures visible using vertical ex vivo dermoscopy in the diagnosis of malignant skin lesions, as well as determining their accuracy in the assessment of tumor margins. A prospective, descriptive study was conducted in two University centers. Digital images of completely excised skin lesions, fixed in formalin, before histopathological diagnosis were used for analysis. BCCs had the most diverse dermoscopic presentation on the vertical section, while SCCs showed a similar presentation in most cases. Vertical dermoscopy of thin melanomas was almost identical, unlike nodular melanomas. Thickness accuracy assessed by dermatologist was 0.753 for BCC, 0.810 for SCC, and 0.800 for melanomas, whereas assessment by pathologist was 0.654, 0.752, and 0.833, respectively. The accuracy of tumor width assessment was 0.819 for BCCs, 0.867 for SCCs and 1.000 for melanoma as estimated by a Dermatologist. Interobserver agreement was 0.71 for BCC, 0.799 for SCC and 0.832 for melanomas. Vertical ex vivo dermoscopy may contribute to the distinction between BCCs, SCCs, and melanomas. Moreover, regardless of the doctor's specialty, it enables a good assessment of the tumor's margins.

摘要

垂直离体皮肤镜检查在临床诊断中的作用尚未得到研究。研究目的是定义、描述并确定使用垂直离体皮肤镜检查可见的结构在恶性皮肤病变诊断中的重要性，以及确定其在评估肿瘤边缘方面的准确性。在两个大学中心进行了一项前瞻性描述性研究。在组织病理学诊断之前，对固定在福尔马林中的完全切除的皮肤病变的数字图像进行分析。基底细胞癌在垂直切片上的皮肤镜表现最为多样，而鳞状细胞癌在大多数情况下表现相似。薄型黑色素瘤的垂直皮肤镜检查几乎相同，与结节型黑色素瘤不同。皮肤科医生评估的厚度准确性，基底细胞癌为0.753，鳞状细胞癌为0.810，黑色素瘤为0.800，而病理科医生评估的分别为0.654、0.752和0.833。皮肤科医生估计，基底细胞癌肿瘤宽度评估的准确性为0.819，鳞状细胞癌为0.867，黑色素瘤为1.000。观察者间一致性，基底细胞癌为0.71，鳞状细胞癌为0.799，黑色素瘤为0.832。垂直离体皮肤镜检查可能有助于区分基底细胞癌、鳞状细胞癌和黑色素瘤。此外，无论医生的专业如何，它都能对肿瘤边缘进行良好的评估。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c85/11351155/c5903866dc2f/biomedicines-12-01683-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c85/11351155/6baab4f40f93/biomedicines-12-01683-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c85/11351155/31f20f2e05bd/biomedicines-12-01683-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c85/11351155/ae190944f32b/biomedicines-12-01683-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c85/11351155/ea2bed6d9d53/biomedicines-12-01683-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c85/11351155/ea7a128f063c/biomedicines-12-01683-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c85/11351155/d3e99f6032c7/biomedicines-12-01683-g011.jpg
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本文引用的文献

1
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JAAD Int. 2022 May 28;8:56-57. doi: 10.1016/j.jdin.2022.04.009. eCollection 2022 Sep.
2
A Practical Method to Prevent Cross-Infection When Performing Dermoscopy.一种在进行皮肤镜检查时预防交叉感染的实用方法。
Dermatol Pract Concept. 2021 Jan 29;11(1):e2021110. doi: 10.5826/dpc.1101a110. eCollection 2021 Jan.
3
Research in Dermoscopy: The Best Is Yet to Come!皮肤镜检查研究：更美好的未来即将到来！
Dermatol Pract Concept. 2021 Jan 29;11(1):e2021084. doi: 10.5826/dpc.1101a84. eCollection 2021 Jan.
4
Relationship between dermoscopy and pathology in a case of clonal-type pigmented Bowen's disease: Observation with vertical-view dermoscopy.克隆型色素性 Bowen 病一例的皮肤镜与病理的关系：垂直观察皮肤镜的观察。
J Dermatol. 2019 May;46(5):436-439. doi: 10.1111/1346-8138.14814. Epub 2019 Feb 15.
5
Vertical plane ex vivo dermoscopy: a novel dermoscopic technique. A preliminary study.垂直平面离体皮肤镜检查：一种新型皮肤镜检查技术。一项初步研究。
An Bras Dermatol. 2018 Nov/Dec;93(6):899-901. doi: 10.1590/abd1806-4841.20187863.
6
Dermoscopy and dermatopathology correlates of cutaneous neoplasms.皮肤肿瘤的皮肤镜与皮肤病理学相关性。
J Am Acad Dermatol. 2019 Feb;80(2):341-363. doi: 10.1016/j.jaad.2018.07.073. Epub 2018 Oct 13.
7
Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions.皮肤肿瘤性病变的皮肤镜检查：最新进展、更新和修订。
Curr Treat Options Oncol. 2018 Sep 20;19(11):56. doi: 10.1007/s11864-018-0573-6.
8
Sensitivity and specificity of ex vivo dermatoscopy: a case series.体外皮肤镜检查的敏感性和特异性：病例系列。
Int J Dermatol. 2018 Aug;57(8):915-921. doi: 10.1111/ijd.14042. Epub 2018 May 23.
9
What's in a Name-Dermoscopy vs Dermatoscopy.名称中的奥秘——皮肤镜检查与皮肤透照检查
JAMA Dermatol. 2017 Dec 1;153(12):1235. doi: 10.1001/jamadermatol.2017.3905.
10
Basics of Confocal Microscopy and the Complexity of Diagnosing Skin Tumors: New Imaging Tools in Clinical Practice, Diagnostic Workflows, Cost-Estimate, and New Trends.共聚焦显微镜检查基础与皮肤肿瘤诊断的复杂性：临床实践中的新型成像工具、诊断流程、成本估算及新趋势
Dermatol Clin. 2016 Oct;34(4):367-375. doi: 10.1016/j.det.2016.05.001. Epub 2016 Jul 27.