Department of Dermatology, Nara Medical University, Kashihara, Japan.
Department of Dermatology, Tenri Hospital, Tenri, Japan.
J Dermatol. 2019 Apr;46(4):347-350. doi: 10.1111/1346-8138.14804. Epub 2019 Feb 15.
Favus is a type of dermatophytosis known to produce yellow scutula around hair follicles. Most cases of this disease worldwide are infections of Trichophyton schoenleinii. Favus has rarely been reported in Japan throughout the last four decades, and T. schoenleinii has not been clinically isolated in any case during the period. Here, we report a case of favus of vellus hair observed in a 63-year-old Japanese woman. Fungal culture showed negative; however, we detected fungal elements in the crust and hair bulbs by Grocott staining. Pathogenic fungi were identified as T. schoenleinii by polymerase chain reaction-based DNA sequencing, targeting the internal transcribed spacer regions of the rRNA gene using the formalin-fixed, paraffin-embedded tissue sample. She was successfully treated with p.o. administration of terbinafine and topical application of luliconazole cream.
黄癣是一种已知的皮肤癣菌病，会在毛囊周围产生黄色鳞屑。全世界大多数此类疾病都是由须癣毛癣菌引起的。在过去的四十年中，日本很少有黄癣的报道，在此期间也从未从临床分离出须癣毛癣菌。在此，我们报告一例 63 岁日本女性发生的毳毛黄癣。真菌培养结果为阴性；然而，我们通过 Grocott 染色在痂皮和毛球中检测到真菌成分。通过聚合酶链反应（PCR）基于 DNA 测序，对福尔马林固定、石蜡包埋组织样本中的核糖体 RNA 基因的内部转录间隔区进行靶向分析，鉴定病原菌为须癣毛癣菌。该患者口服特比萘芬和外用卢立康唑乳膏治疗后痊愈。
