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Anat Rec (Hoboken). 2020 Jun;303(6):1584-1589. doi: 10.1002/ar.24089. Epub 2019 Mar 15.
CD147, also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or basigin, is expressed in a variety of cell types. It is involved in the regulation of extracellular matrix (ECM) remodeling during physiological and pathological processes including wound healing, inflammatory diseases, and cancer. CD147 is a diagnostic and therapeutic target in cancer and inflammatory diseases, either directly or indirectly, by targeting CD147 partners. It can trigger matrix metalloproteinase inductions involved in ECM degradation, cell adhesion, and cell-cell interactions. It can also induce myofibroblast differentiation associated with ECM deposition and contraction. The shift from fibrosis to lysis, and vice versa, is poorly understood and could involve CD147. This article provides an overview of the role of CD147 in the regulation of ECM remodeling processes and discusses the involvement of the microenvironment in the modulation of its downstream effects. Understanding CD147 regulation could help identify new therapeutic intervention. Anat Rec, 2019. © 2019 Wiley Periodicals, Inc.
CD147，也被称为细胞外基质金属蛋白酶诱导因子（EMMPRIN）或 basigin，在多种细胞类型中表达。它参与生理和病理过程中细胞外基质（ECM）重塑的调节，包括伤口愈合、炎症性疾病和癌症。CD147 是癌症和炎症性疾病的诊断和治疗靶点，无论是直接还是间接，通过靶向 CD147 伴侣。它可以触发参与 ECM 降解、细胞黏附和细胞间相互作用的基质金属蛋白酶诱导。它还可以诱导与 ECM 沉积和收缩相关的肌成纤维细胞分化。从纤维化到溶解的转变，反之亦然，目前了解甚少，可能涉及 CD147。本文概述了 CD147 在调节 ECM 重塑过程中的作用，并讨论了微环境在调节其下游效应中的作用。了解 CD147 的调节可能有助于确定新的治疗干预措施。解剖学年鉴，2019 年。© 2019 威利父子公司
