Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Biomed Pharmacother. 2023 Jan;157:113983. doi: 10.1016/j.biopha.2022.113983. Epub 2022 Nov 10.
Cluster of differentiation 147 (CD147) or extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that induces the synthesis of matrix metalloproteinases (MMPs). MMPs, as zinc-dependent proteases and versatile enzymes, play critical roles in the degradation of the extracellular matrix (ECM) components, cleaving of the receptors of cellular surfaces, signaling molecules, and other precursor proteins, which may lead to attenuation or activation of such targets. CD147 and MMPs play essential roles in physiological and pathological conditions and any disorder in the expression, synthesis, or function of CD147 and MMPs may be associated with various types of disease. In this review, we have focused on the roles of CD147 and MMPs in some major physiological and pathological processes.
CD147（分化簇 147）或细胞外基质金属蛋白酶诱导因子（EMMPRIN）是一种跨膜糖蛋白，可诱导基质金属蛋白酶（MMPs）的合成。MMPs 作为锌依赖性蛋白酶和多功能酶，在细胞外基质（ECM）成分的降解、细胞表面受体、信号分子和其他前体蛋白的切割中发挥关键作用，这可能导致这些靶标的抑制或激活。CD147 和 MMPs 在生理和病理条件下发挥重要作用，CD147 和 MMPs 的表达、合成或功能的任何异常都可能与各种类型的疾病相关。在这篇综述中，我们重点介绍了 CD147 和 MMPs 在一些主要生理和病理过程中的作用。
