Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.
Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China.
Ecotoxicol Environ Saf. 2019 May 30;173:54-62. doi: 10.1016/j.ecoenv.2019.02.018. Epub 2019 Feb 12.
Quantum dots (QDs), considered as a type of excellent semiconductor nanomaterial, are widely employed and have a number of important applications. However, QDs have the potential to produce adverse effects and toxicity with the underlying molecular mechanisms not well understood. Herein, Caenorhabditis elegans was used for in vivo toxicity assessment to detect the reproductive toxicity of CdTe QDs. We found that exposure to CdTe QDs particles (≥ 50 mg/L) resulted in a defect in reproductive capacity, dysfunctional proliferation and differentiation, as well as an imbalance in oogenesis by reducing the number of cells in pachytene and diakinesis. Further, we identified a SPO-11 and PCH-2 mediated toxic mechanism and a GLP-1/Notch mediated protective mechanism in response to CdTe QDs particles (≥ 50 mg/L). Taken together, these results demonstrate the potential adverse impact of CdTe QDs (≥ 50 mg/L) exposure on oogenesis and provide valuable data and guidelines for evaluation of QD biocompatibility.
量子点（QDs）被认为是一种优秀的半导体纳米材料，被广泛应用，并具有许多重要的应用。然而，QDs 有可能产生不良影响和毒性，其潜在的分子机制尚不清楚。在此，我们使用秀丽隐杆线虫进行体内毒性评估，以检测 CdTe QDs 的生殖毒性。我们发现，暴露于 CdTe QDs 颗粒（≥50mg/L）会导致生殖能力缺陷、增殖和分化功能障碍，以及通过减少粗线期和减数分裂期细胞数量来破坏卵母细胞发生。此外，我们确定了一种 SPO-11 和 PCH-2 介导的毒性机制以及一种 GLP-1/Notch 介导的保护机制，以应对 CdTe QDs 颗粒（≥50mg/L）。综上所述，这些结果表明 CdTe QDs（≥50mg/L）暴露对卵母细胞发生具有潜在的不良影响，并为 QD 生物相容性的评估提供了有价值的数据和指导。
