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中国普通微生物菌种保藏管理中心9951对聚苯乙烯微塑料诱导的生殖毒性的缓解作用

The Alleviative Effects of CGMCC 9951 on the Reproductive Toxicity of Induced by Polystyrene Microplastics.

作者信息

Li Chengmei, Zhao Lina, Fan Jiajia, Qi Wentong, Li Xuan, Li Yuwan, Tian Pingping, Wu Ying, Gu Shaobin

机构信息

College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.

Henan Engineering Research Center of Food Microbiology, Luoyang 471000, China.

出版信息

Microorganisms. 2025 Feb 24;13(3):497. doi: 10.3390/microorganisms13030497.

DOI:10.3390/microorganisms13030497
PMID:40142390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11944320/
Abstract

The increased emission and accumulation of microplastics pose a severe threat to humans and the environment. As effective biological agents for alleviating the effects of microplastics, the mechanism of action of probiotics remains unclear. In this study, based on the successful establishment of a reproductive virulence model of (), we explored the effect and mechanism of CGMCC 9951 ( CGMCC 9951) on the reproductive toxicity of . Our results showed that the gonad area and the number of offspring increased but the number of germ cells undergoing apoptosis decreased by 14% and 24% in , after CGMCC 9951 treatments. Antioxidant test results showed that CGMCC 9951 increased the activity of Superoxide Dismutase (SOD), Catalase (CAT), and the content of Glutathione (GSH) in . In addition, it was found by qPCR and mutagenesis experiments verified that CGMCC 9951 alleviated reproductive toxicity through the DNA checkpoint signaling pathway. Our findings suggested that CGMCC 9951 could alleviate the reproductive toxicity of polystyrene microplastics in by enhancing antioxidant capacity and inhibiting DNA damage checkpoint signaling pathway. The above results suggest that probiotics can be used as a potential approach to alleviate the reproductive toxicity induced by polystyrene microplastics in humans.

摘要

微塑料排放和积累的增加对人类和环境构成了严重威胁。作为缓解微塑料影响的有效生物制剂，益生菌的作用机制尚不清楚。在本研究中，基于成功建立的（）生殖毒性模型，我们探讨了CGMCC 9951（CGMCC 9951）对（）生殖毒性的影响及机制。我们的结果表明，在CGMCC 9951处理后，（）的性腺面积和后代数量增加，但发生凋亡的生殖细胞数量分别减少了14%和24%。抗氧化试验结果表明，CGMCC 9951提高了（）中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）的活性以及谷胱甘肽（GSH）的含量。此外，通过qPCR发现并经诱变实验验证，CGMCC 9951通过DNA检查点信号通路减轻生殖毒性。我们的研究结果表明，CGMCC 9951可通过增强抗氧化能力和抑制DNA损伤检查点信号通路来减轻聚苯乙烯微塑料对（）的生殖毒性。上述结果表明，益生菌可作为一种潜在方法来减轻聚苯乙烯微塑料对人类生殖毒性的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/78b8b6b2d8d1/microorganisms-13-00497-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/c57918675712/microorganisms-13-00497-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/bdd8fdc1f77b/microorganisms-13-00497-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/5941b47e1715/microorganisms-13-00497-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/a369930f43e7/microorganisms-13-00497-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/0967f2679be9/microorganisms-13-00497-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/e5059cb68c5c/microorganisms-13-00497-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/06186ededdc5/microorganisms-13-00497-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/78b8b6b2d8d1/microorganisms-13-00497-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/c57918675712/microorganisms-13-00497-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/bdd8fdc1f77b/microorganisms-13-00497-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/5941b47e1715/microorganisms-13-00497-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/a369930f43e7/microorganisms-13-00497-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/0967f2679be9/microorganisms-13-00497-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/e5059cb68c5c/microorganisms-13-00497-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/06186ededdc5/microorganisms-13-00497-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11944320/78b8b6b2d8d1/microorganisms-13-00497-g008.jpg

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