用于肾脏疾病诊断与理解的代谢组学方法

Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases.

作者信息

Abbiss Hayley, Maker Garth L, Trengove Robert D

机构信息

School of Veterinary and Life Sciences, Murdoch University, 90 South Street, Perth 6150, Australia.

Separation Science and Metabolomics Laboratory, Murdoch University, 90 South Street, Perth 6150, Australia.

出版信息

Metabolites. 2019 Feb 14;9(2):34. doi: 10.3390/metabo9020034.

DOI:10.3390/metabo9020034

PMID:30769897

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6410198/

Abstract

Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer, kidney transplantation and polycystic kidney diseases. Numerous studies have adopted a metabolomics approach to uncover new small molecule biomarkers of kidney diseases to improve specificity and sensitivity of diagnosis and to uncover biochemical mechanisms that may elucidate the cause and progression of these diseases. This work includes a description of mass spectrometry-based metabolomics approaches, including some of the currently available tools, and emphasises findings from metabolomics studies of kidney diseases. We have included a varied selection of studies (disease, model, sample number, analytical platform) and focused on metabolites which were commonly reported as discriminating features between kidney disease and a control. These metabolites are likely to be robust indicators of kidney disease processes, and therefore potential biomarkers, warranting further investigation.

摘要

肾脏疾病难以诊断和治疗。本综述总结了其中一些疾病的定义、病因、流行病学和治疗方法，包括慢性肾脏病、糖尿病肾病、急性肾损伤、肾癌、肾移植和多囊肾病。众多研究采用代谢组学方法来发现肾脏疾病新的小分子生物标志物，以提高诊断的特异性和敏感性，并揭示可能阐明这些疾病病因和进展的生化机制。这项工作包括对基于质谱的代谢组学方法的描述，包括一些目前可用的工具，并强调肾脏疾病代谢组学研究的结果。我们纳入了各种不同的研究（疾病、模型、样本数量、分析平台），并重点关注那些通常被报道为肾脏疾病与对照之间鉴别特征的代谢物。这些代谢物可能是肾脏疾病进程的可靠指标，因此是潜在的生物标志物，值得进一步研究。