外显子测序与代谢组学相结合以建立胃癌分子分型系统。
The combination of exon sequencing and metabolomics to establish a molecular typing system for gastric cancer.
作者信息
Yu Shanshan, Chen Ming, Zhu Xiaohua, Chen Cheng, Liang Jinxiao, Wang Haiyong, Lu Jun, Ding Yongfeng, Kong Mei, Teng Lisong, Zhou Donghui
机构信息
Department of Surgical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.
出版信息
Heliyon. 2024 Jul 9;10(15):e34317. doi: 10.1016/j.heliyon.2024.e34317. eCollection 2024 Aug 15.
BACKGROUND
Gastric cancer (GC) is one of the most common malignant tumors in the world. It has become increasingly difficult to meet the needs of precision therapy using the existing molecular typing system. Therefore, developing a more effective molecular typing system for GC is urgent.
METHODS
In this study, 100 Chinese GC patients were included. Whole-exome sequencing (WES) and metabolomics analysis were performed to reveal the characteristics of genomic and metabolic changes.
RESULTS
In WES, nonsynonymous mutations accounted for the majority. Based on metabolomics, GC has been divided into three subtypes with distinct metabolic features. Importantly, we ultimately divided GC into four subtypes with different metabolic characteristics, genomic alterations, and clinical prognoses by incorporating biomics analysis.
CONCLUSIONS
Integrating biological features, we constructed a novel molecular system for GC that was closely related to genetics and metabolism, providing new insights for further understanding the heterogeneity and formulating precise treatment strategies.
背景
胃癌（GC）是世界上最常见的恶性肿瘤之一。利用现有的分子分型系统来满足精准治疗的需求变得越来越困难。因此，为胃癌开发一种更有效的分子分型系统迫在眉睫。
方法
在本研究中，纳入了100例中国胃癌患者。进行了全外显子测序（WES）和代谢组学分析，以揭示基因组和代谢变化的特征。
结果
在全外显子测序中，非同义突变占大多数。基于代谢组学，胃癌已被分为具有不同代谢特征的三个亚型。重要的是，通过整合生物组学分析，我们最终将胃癌分为具有不同代谢特征、基因组改变和临床预后的四个亚型。
结论
整合生物学特征，我们构建了一种与遗传和代谢密切相关的新型胃癌分子系统，为进一步理解异质性和制定精准治疗策略提供了新的见解。
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