Tonacci Alessandro, Quattrocchi Paolina, Gangemi Sebastiano
National Research Council of Italy, Institute of Clinical Physiology (CNR-IFC), Via Moruzzi 1, 56124 Pisa, Italy.
School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Medicina (Kaunas). 2019 Feb 14;55(2):50. doi: 10.3390/medicina55020050.
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions. The IL-33/ST2 axis plays an important role in several acute and chronic inflammatory diseases, including asthma and rheumatoid arthritis. Different disorders are related to the activity of IL-33, ST2, or their axis, including cardiovascular disease or renal disturbances. Therefore, in the present work, a literature review was conducted, covering the period from 1 January 2000 to 30 November 2018, in PubMed, ScienceDirect, and Google Scholar database, to assess the involvement of the IL-33/ST2 axis in diabetic kidney disease. 6 articles directly dealing with the argument were identified, highlighting a clear link between IL-33/ST2 axis and diabetic kidney disease or related nephropathy. Overall, the involvement of ST2 seems to be more predictive than IL-33, especially in investigating the deterioration of kidney function; however, both compounds are pivotal in the field of renal diseases. Future studies are required to confirm the scientific evidences on larger and more heterogeneous cohorts.
白细胞介素-33（IL-33）是一种属于IL-1家族的细胞因子，在炎症、感染和自身免疫性疾病中发挥作用，并在多种组织的细胞核中表达。上皮屏障组织和内皮屏障中表达高水平的IL-33。ST2是IL-33的受体，选择性地表达于一部分Th2细胞上，介导其部分功能。IL-33/ST2轴在包括哮喘和类风湿性关节炎在内的多种急慢性炎症性疾病中起重要作用。不同的病症与IL-33、ST2或其轴的活性相关，包括心血管疾病或肾脏疾病。因此，在本研究中，我们在PubMed、ScienceDirect和谷歌学术数据库中进行了一项文献综述，涵盖2000年1月1日至2018年11月30日期间，以评估IL-33/ST2轴在糖尿病肾病中的作用。共鉴定出6篇直接涉及该论点的文章，突出了IL-33/ST2轴与糖尿病肾病或相关肾病之间的明确联系。总体而言，ST2的参与似乎比IL-33更具预测性，尤其是在研究肾功能恶化方面；然而，这两种化合物在肾脏疾病领域都至关重要。未来的研究需要在更大且更具异质性的队列中证实这些科学证据。
