Department of Gastrointestinal Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Biochem Biophys Res Commun. 2019 Mar 26;511(1):57-62. doi: 10.1016/j.bbrc.2019.02.030. Epub 2019 Feb 12.
Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In the present study, we explored the expression and biological role of the lncRNA DNM3OS in gastric cancer (GC). We observed that DNM3OS was upregulated in GC tissues and cell lines, and high DNM3OS expression was correlated with malignant features and served as an indicator of a poor prognosis for GC patients. DNM3OS knockdown inhibited the proliferation of GC cells, and reduced DNM3OS suppressed tumor growth in vivo. Moreover, DNM3OS depletion inhibited the migration and invasion of GC cells through the suppression of the Snail-mediated epithelial-mesenchymal transition (EMT). In conclusion, we demonstrated that DNM3OS serves as an oncogenic lncRNA in GC, and we implicated DNM3OS as a promising prognostic factor and a potential therapeutic target for GC patients.
长链非编码 RNA（lncRNAs）在肿瘤的发生和发展中作为肿瘤抑制因子或癌基因发挥作用。在本研究中，我们探讨了 lncRNA DNM3OS 在胃癌（GC）中的表达和生物学作用。我们观察到 DNM3OS 在 GC 组织和细胞系中上调，并且高表达 DNM3OS 与恶性特征相关，并作为 GC 患者预后不良的指标。DNM3OS 敲低抑制 GC 细胞的增殖，并且体内抑制 DNM3OS 抑制肿瘤生长。此外，DNM3OS 耗竭通过抑制 Snail 介导的上皮-间充质转化（EMT）抑制 GC 细胞的迁移和侵袭。总之，我们证明 DNM3OS 作为 GC 中的致癌 lncRNA 发挥作用，并暗示 DNM3OS 作为 GC 患者有前途的预后因素和潜在的治疗靶点。
