长链非编码 RNA DNM3OS：在病理生理过程中的致病作用和分子机制。
Long Non-coding RNA DNM3OS: Pathogenic Roles and Molecular Mechanisms in Pathophysiological Processes.
机构信息
Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China.
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Department of Biochemistry, China Three Gorges University, Yichang, 443002, China.
出版信息
Curr Med Chem. 2024;31(29):4687-4702. doi: 10.2174/0109298673280484240101070607.
BACKGROUND
Long non-coding RNA (lncRNA) is a class of single-stranded RNA biomolecules involving over 200 nucleotides and does not encode proteins. Research on lncRNA has become a hot spot for the past few years. DNM3OS (Dynamin 3 Opposite Strand), which has been clearly identified as a regulatory lncRNA, exerts an integral role in the pathophysiology of multiple human diseases.
OBJECTIVE
The current review study summarizes the pathogenic mechanism of DNM3OS in various pathophysiological processes, aiming to reveal its important value as a therapeutic drug target for related human diseases and provide a new way for targeted therapy.
METHODS
Through systematic retrieval and in-depth study of relevant articles in PubMed, this article analyzes and summarizes the pathogenic roles and molecular mechanisms in pathophysiological processes of long non-coding RNA DNM3OS.
RESULTS
DNM3OS exerts an important regulatory role in the occurrence and development of bone diseases, neoplastic diseases, fibrotic diseases, inflammatory diseases, and many other diseases.
CONCLUSION
DNM3OS is a potential new biomarker and therapeutic target for the treatment of a series of diseases, consisting of bone diseases, neoplastic diseases, fibrotic diseases, and inflammatory diseases.
背景
长链非编码 RNA（lncRNA）是一类涉及超过 200 个核苷酸且不编码蛋白质的单链 RNA 生物分子。近年来，lncRNA 的研究已成为热点。DNM3OS（动力蛋白 3 反义链）已明确被鉴定为一种调控 lncRNA，其在多种人类疾病的病理生理学中发挥着重要作用。
目的
本综述研究总结了 DNM3OS 在各种病理生理过程中的致病机制，旨在揭示其作为相关人类疾病治疗药物靶点的重要价值，并为靶向治疗提供新途径。
方法
通过系统检索和深入研究 PubMed 中的相关文章，本文分析和总结了长链非编码 RNA DNM3OS 在病理生理过程中的致病作用和分子机制。
结果
DNM3OS 在骨疾病、肿瘤性疾病、纤维化疾病、炎症性疾病等多种疾病的发生发展中发挥着重要的调控作用。
结论
DNM3OS 是一系列疾病（包括骨疾病、肿瘤性疾病、纤维化疾病和炎症性疾病）治疗的潜在新生物标志物和治疗靶点。
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