Gunn A J, Williams C E, Bennet L, Cook C J, Gluckman P D
Department of Paediatrics, University of Auckland, New Zealand.
Fetal Ther. 1988;3(1-2):98-107. doi: 10.1159/000263339.
Perinatal asphyxia is associated with an increased risk of cerebral palsy and significant mortality. We investigated the use of flunarizine, a calcium antagonist and MK-801, an excitatory amino acid antagonist, in preventing the sequelae of severe hypoxic/ischemic insults. Flunarizine was neuroprotective in the infant rat subjected to unilateral carotid ligation and 2 h of hypoxia. Preliminary analysis of experiments in a novel model of cerebral ischemia in the fetal sheep suggests that prophylactic treatment with flunarizine greatly modified the outcome after 30 min of total ischemia. Treatment with MK-801 prevented post-ischemic seizures. The background to these developments is outlined and future prospects considered.
围产期窒息与脑瘫风险增加及显著死亡率相关。我们研究了钙拮抗剂氟桂利嗪和兴奋性氨基酸拮抗剂MK-801在预防严重缺氧/缺血性损伤后遗症方面的应用。氟桂利嗪对接受单侧颈动脉结扎和2小时缺氧的幼鼠具有神经保护作用。对新生胎羊脑缺血新模型实验的初步分析表明，氟桂利嗪预防性治疗可显著改善全脑缺血30分钟后的结果。MK-801治疗可预防缺血后癫痫发作。本文概述了这些进展的背景并探讨了未来前景。
