Shandong University, 44 Culture Western Road, Lixia District, Jinan, Shandong Province 250013, China.
Jinan Municipal Center for Disease Control and Prevention, 2 Weiliu Road, Huaiyin District, Jinan, Shandong Province 250021, China.
Vaccine. 2019 Mar 7;37(11):1436-1442. doi: 10.1016/j.vaccine.2019.01.060. Epub 2019 Feb 13.
Few studies have reported on the epidemiological characteristics of pediatric primary intussusception in the pre-rotavirus vaccine era of China. It is important to complementary baseline data before rotavirus vaccine introduction in China. This study conduct a retrospective investigation and evaluated the incidence rate, described the epidemiology of pediatric primary intussusception aged ≤24 months.
We conducted a retrospective investigation in all secondary- and tertiary-hospitals in Jinan. Pediatric primary intussusception inpatients aged ≤24 months were identified depending on ICD-10 discharge code from a total of 63 hospitals from 2011 to 2015. Demographic and clinical information were extracting from the electronic clinical record systems.
A total of 575 pediatric primary intussusception inpatients were identified with average annual incidence of 86.5 per 100,000. A significantly higher incidence was observed in males (χ2 = 13.8, P < 0.01), in the ≤12 months old age group (χ2 = 19.5, P < 0.01) and from the urban areas (χ2 = 63.31, P < 0.001). No clear seasonality found. Abdominal pain (80.9%) and vomiting (63.3%) were the most frequently reported. Most intussusception cases occurred in ileo-cecum. Over 92% of intussusception cases were diagnosed by ultrasound alone and 77.4% was successfully treated by air enema. 99.7% were cured. The median time of hospitalization was 2 days (range: 0-35 days).
This retrospective study provides baseline information of incidence, epidemiologyand clinical characteristics of pediatric primary intussusception in Jinan City during 2011-2016 before the introduction of rotavirus vaccine. It will be important for evaluating safety of rotavirus vaccine if it will be introduced to the routine immunization program in China.
在中国轮状病毒疫苗问世之前，鲜有研究报告儿科原发性肠套叠的流行病学特征。在轮状病毒疫苗引入中国之前，获得补充的基线数据非常重要。本研究对济南市的儿科原发性肠套叠发病率进行了回顾性调查，并评估了≤24 月龄儿童的流行病学特征。
我们对济南市所有二级和三级医院进行了回顾性调查。从 2011 年至 2015 年，从 63 家医院的 ICD-10 出院代码中确定了所有≤24 月龄的住院儿科原发性肠套叠患儿。从电子病历系统中提取人口统计学和临床信息。
共确定了 575 例儿科原发性肠套叠住院患儿，其年发病率平均为 86.5/10 万。男性（χ2=13.8，P＜0.01）、≤12 月龄（χ2=19.5，P＜0.01）和城区（χ2=63.31，P＜0.001）患儿的发病率显著更高。未发现明显的季节性。腹痛（80.9%）和呕吐（63.3%）是最常见的报告症状。大多数肠套叠发生在回盲部。超过 92%的肠套叠病例仅通过超声诊断，77.4%的肠套叠病例通过气钡灌肠成功治疗。99.7%的患儿治愈。住院中位时间为 2 天（范围：0-35 天）。
本回顾性研究提供了 2011 年至 2016 年轮状病毒疫苗问世前济南市儿科原发性肠套叠的发病率、流行病学和临床特征的基线信息。如果轮状病毒疫苗被纳入中国常规免疫计划，它将对评估其安全性非常重要。
