自身免疫中的免疫细胞代谢。
Immune cell metabolism in autoimmunity.
机构信息
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
出版信息
Clin Exp Immunol. 2019 Aug;197(2):181-192. doi: 10.1111/cei.13277. Epub 2019 Mar 11.
Abstract
Immune metabolism is a rapidly moving field. While most of the research has been conducted to define the metabolism of healthy immune cells in the mouse, it is recognized that the overactive immune system that drives autoimmune diseases presents metabolic abnormalities that provide therapeutic opportunities, as well as a means to understand the fundamental mechanisms of autoimmune activation more clearly. Here, we review recent publications that have reported how the major metabolic pathways are affected in autoimmune diseases, with a focus on rheumatic diseases.
摘要
免疫代谢是一个快速发展的领域。虽然大部分研究都是在小鼠中定义健康免疫细胞的代谢，但人们已经认识到，驱动自身免疫疾病的过度活跃的免疫系统会出现代谢异常，这为治疗提供了机会，也为更清楚地了解自身免疫激活的基本机制提供了一种手段。在这里，我们回顾了最近的一些出版物，这些出版物报道了自身免疫性疾病中主要代谢途径是如何受到影响的，重点是风湿性疾病。
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