Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China.
Front Immunol. 2022 Feb 28;13:799331. doi: 10.3389/fimmu.2022.799331. eCollection 2022.
Trace element iron affects T cell biology, but the knowledge about the role of iron in regulating Treg cell expansion is limited. Treg cells play an important role in keeping peripheral T cell tolerance, increasing Treg cell expansion is a promising therapeutic method for SLE. Here we showed that iron deficiency promotes Treg cell expansion by reducing ROS accumulation, improving the disease progression of pristane-induced lupus. Increased oxidative stress inhibits Treg cell differentiation by inducing cell apoptosis. Our data suggest that altering iron metabolism promotes Treg cell expansion by preventing oxidation-induced cell death, which may provide a potential therapeutic strategy for SLE.
微量元素铁影响 T 细胞生物学，但关于铁在调节 Treg 细胞扩增中的作用的知识有限。Treg 细胞在维持外周 T 细胞耐受方面发挥重要作用，增加 Treg 细胞扩增是治疗系统性红斑狼疮的一种有前途的方法。在这里，我们表明缺铁通过减少 ROS 积累促进 Treg 细胞扩增，从而改善了 pristane 诱导的狼疮的疾病进展。增加的氧化应激通过诱导细胞凋亡抑制 Treg 细胞分化。我们的数据表明，改变铁代谢通过防止氧化诱导的细胞死亡来促进 Treg 细胞扩增，这可能为治疗 SLE 提供一种潜在的治疗策略。
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