Seiri Parvaneh, Abi Abbas, Soukhtanloo Mohammad
Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Biochem. 2019 Jul;120(7):10893-10908. doi: 10.1002/jcb.28419. Epub 2019 Feb 15.
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. PPARs are categorized into three subtypes, PPARα, β/δ, and γ, encoded by different genes, expressed in diverse tissues and participate in various biological functions and can be activated by their metabolic derivatives in the body or dietary fatty acids. The PPAR-γ also takes parts in the regulation of energy balance, lipoprotein metabolism, insulin sensitivity, oxidative stress, and inflammatory signaling. It has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis, and cancers. Among various cellular and molecular targets that are able to regulate PPAR-γ and its underlying pathways, microRNAs (miRNAs) appeared as important regulators. Given that the deregulation of these molecules via targeting PPAR-γ could affect initiation and progression of various diseases, identification of miRNAs that affects PPAR-γ could contribute to the better understanding of roles of PPAR-γ in various biological and pathological conditions. Here, we have summarized the function and various ligands of PPAR-γ and have highlighted various miRNAs involved in the regulation of PPAR-γ.
过氧化物酶体增殖物激活受体（PPARs）属于核受体超家族。PPARs分为三种亚型，即PPARα、β/δ和γ，由不同基因编码，在多种组织中表达，参与各种生物学功能，并可被体内的代谢衍生物或膳食脂肪酸激活。PPAR-γ还参与能量平衡、脂蛋白代谢、胰岛素敏感性、氧化应激和炎症信号的调节。它与包括肥胖、糖尿病、动脉粥样硬化和癌症在内的多种疾病的病理过程有关。在能够调节PPAR-γ及其潜在途径的各种细胞和分子靶点中，微小RNA（miRNAs）成为重要的调节因子。鉴于通过靶向PPAR-γ对这些分子的失调可能影响各种疾病的发生和发展，鉴定影响PPAR-γ的miRNAs有助于更好地理解PPAR-γ在各种生物学和病理条件下的作用。在此，我们总结了PPAR-γ的功能和各种配体，并强调了参与调节PPAR-γ的各种miRNAs。
